De Waard M, Gurnett C A, Campbell K P
Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City 52242, USA.
Ion Channels. 1996;4:41-87. doi: 10.1007/978-1-4899-1775-1_2.
Data gathered from the expression of cDNAs that encode the subunits of voltage-dependent Ca2+ channels have demonstrated important structural and functional similarities among these channels. Despite these convergences, there are also significant differences in the nature and functional importance of subunit-subunit and protein-Ca2+ channel interactions. There is evidence demonstrating that the functional differences between Ca2+ channel subtypes is due to several factors, including the expression of distinct alpha 1 subunit proteins, the selective association of structural subunits and modulatory proteins, and differences in posttranslational processing and cell regulation. We summarize several avenues of research that should provide significant clues about the structural features involved in the biophysical and functional diversity of voltage-dependent Ca2+ channels.
从编码电压依赖性钙通道亚基的cDNA表达中收集的数据表明，这些通道之间存在重要的结构和功能相似性。尽管存在这些趋同性，但亚基-亚基和蛋白质-钙通道相互作用的性质和功能重要性也存在显著差异。有证据表明，钙通道亚型之间的功能差异是由多种因素造成的，包括不同α1亚基蛋白的表达、结构亚基和调节蛋白的选择性结合，以及翻译后加工和细胞调节的差异。我们总结了几条研究途径，这些途径应该能为电压依赖性钙通道的生物物理和功能多样性所涉及的结构特征提供重要线索。
