Błaszczyk B, Inglot A D, Toivanen P, Młochowski J, Szymaniec S
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Arch Immunol Ther Exp (Warsz). 1995;43(5-6):299-303.
Two week old chickens were treated once daily for 5 days with AE8--1-pyridyl-1,2-benzisoselenazol-3(2H)-one, AE22--bis-2-(N-phenyle-carboxamido) 1 pyridyl diselenide and AE31--bis(phenylo-diselenide with R3 = CONHC18H37). Their whole blood alone or blood mixed with thymus cells were used to generate graft versus host (GvH) reaction in 15 day old chicken embryos. The treatment of the chickens with the compounds stimulated the GvH reaction modifying activity of the donor cells as measured by increase of the spleen weight of the recipient chicken embryos. On the other hand, treatment with these compounds inhibited the IgG or IgM production in chickens immunized with human albumin.
对两周龄的小鸡，每天用AE8（1-吡啶基-1,2-苯并异硒唑-3(2H)-酮）、AE22（双-2-(N-苯基甲酰胺基) 1-吡啶基二硒化物）和AE31（R3 = CONHC18H37的双(苯基二硒化物)）处理一次，持续5天。单独使用它们的全血或与胸腺细胞混合的血液，用于在15日龄鸡胚中引发移植物抗宿主（GvH）反应。用这些化合物处理小鸡后，通过受体鸡胚脾脏重量的增加来衡量，刺激了供体细胞的GvH反应修饰活性。另一方面，用这些化合物处理抑制了用人白蛋白免疫的小鸡中IgG或IgM的产生。
