Shen K, Lang J, Guo L
Peking Union Medical College Hospital, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 1995 Nov;30(11):658-61.
To determine the prevalence of C-erbB3 abnormal protein expression in transitional cell carcinoma of the ovary in our hospital and to analyse the correlation between the overexpression of C-erbB3 protein and prognostic parameters of transitional cell carcinoma of the ovary.
Thirty-two transitional cell carcinoma of the ovary and 20 normal ovaries were studied for overexpression of C-erbB3 protein by immunohistochemical staining (IHS), using the monoclonal antibody RJT2 on paraffin sections.
Forty seven percent of 32 samples of transitional cell carcinoma of the ovary showed positive IHS with RJT2, and 39% of 20 normal ovaries showed positive cytoplasmic and membrane staining (P > 0.05). C-erbB3 overexpression did not correlate with age, CA125 levels, histological grade and lymph node metastases, but patients with overexpression of C-erbB3 had a poorer prognosis.
Overexpression of C-erbB3 is a common event in transitional cell carcinoma of ovary. Further studies are warranted to clarify the role of C-erbB3 in transitional cell carcinoma of the ovary.
确定我院卵巢移行细胞癌中C-erbB3异常蛋白表达的患病率，并分析C-erbB3蛋白过表达与卵巢移行细胞癌预后参数之间的相关性。
采用单克隆抗体RJT2，通过免疫组织化学染色（IHS）对32例卵巢移行细胞癌和20例正常卵巢组织石蜡切片进行C-erbB3蛋白过表达研究。
32例卵巢移行细胞癌样本中有47%经RJT2免疫组织化学染色呈阳性，20例正常卵巢组织中有39%呈细胞质和细胞膜染色阳性（P>0.05）。C-erbB3过表达与年龄、CA125水平、组织学分级和淋巴结转移无关，但C-erbB3过表达的患者预后较差。
C-erbB3过表达在卵巢移行细胞癌中较为常见。有必要进一步研究以阐明C-erbB3在卵巢移行细胞癌中的作用。
