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[阻塞性睡眠呼吸暂停综合征与心血管疾病]

[Obstructive sleep apnea syndrome and cardiovascular diseases].

作者信息

Théolade R, Seibert R, Goerlich E, Michel A, Grandjean P, Ruscher H, Weitzenblum E

机构信息

Service de Médecine interne, Centre Hospitalier Général, Wissembourg.

出版信息

Ann Cardiol Angeiol (Paris). 1995 Nov;44(9):507-16.

PMID:8745661
Abstract

Obstructive sleep apnoea syndrome is due to pharyngeal obstruction of inspiratory airflow with preservation of thoraco-abdominal respiratory movements. This disease has been described for about thirty years, but is now the subject of growing interest. According to the increasingly abundant literature on this subject, OSAS is associated with essentially cardiovascular morbidity and mortality (systemic hypertension, pulmonary hypertension, heart failure, coronary heart disease, arrhythmias, cerebral vascular accidents and sudden death). The pathophysiology of its underlying mechanisms and its complications is complex and multifactorial. The diagnosis of this syndrome should be suspected on clinical interview (snoring, excessive daytime drowsiness, and apnoea during sleep) and is confirmed by polysomnography. Nasal continuous positive pressure with elimination of aggravating factors is the reference treatment in 1994. The diagnosis and management of this syndrome requires a multidisciplinary approach with collaboration between general practitioners, neurologists, maxillofacial/ENT surgeons, cardiologists and respiratory physicians.

摘要

阻塞性睡眠呼吸暂停综合征是由于吸气气流的咽部阻塞,同时保留胸腹呼吸运动。这种疾病已经被描述了大约三十年,但现在越来越受到关注。根据关于这个主题的文献越来越丰富,阻塞性睡眠呼吸暂停综合征主要与心血管发病率和死亡率相关(系统性高血压、肺动脉高压、心力衰竭、冠心病、心律失常、脑血管意外和猝死)。其潜在机制及其并发症的病理生理学是复杂且多因素的。该综合征的诊断应在临床问诊时怀疑(打鼾、白天过度嗜睡和睡眠期间呼吸暂停),并通过多导睡眠图确诊。消除加重因素的鼻持续正压通气是1994年的参考治疗方法。该综合征的诊断和管理需要多学科方法,由全科医生、神经科医生、颌面/耳鼻喉科外科医生、心脏病专家和呼吸内科医生协作。

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