Welch K M, Ramadan N M
Department of Neurology, K-11 Henry Ford Hospital and Health Sciences Center, Detroit, MI 48202, USA.
J Neurol Sci. 1995 Dec;134(1-2):9-14. doi: 10.1016/0022-510x(95)00196-1.
The evidence for disordered mitochondrial oxidative phosphorylation and reduced intracellular free magnesium in brain and body tissue of migraine suffers both between and during an attack is reviewed. We propose that between attacks these metabolic shifts cause instability of neuronal function which enhances the susceptibility of brain to develop a migraine attack.
本文综述了偏头痛患者在发作间期及发作期间，其大脑和身体组织中线粒体氧化磷酸化紊乱及细胞内游离镁减少的证据。我们认为，在发作间期，这些代谢变化会导致神经元功能不稳定，从而增加大脑发生偏头痛发作的易感性。
