Montagna P, Cortelli P, Barbiroli B
Center for the Study of Headache and Cranial Neuralgia, University of Bologna, Italy.
Cephalalgia. 1994 Jun;14(3):184-93. doi: 10.1046/j.1468-2982.1994.014003184.x.
We describe the method of 31phosphorous magnetic resonance spectroscopy and review the results when it is applied to the study of brain and muscle energy metabolism in migraine subjects. Brain energy metabolism appears to be abnormal in all major subtypes of migraine when measured both during and between attacks. Impaired energy metabolism is also documented in skeletal muscle. We suggest that migraine is associated with a generalized disorder of mitochondrial oxidative phosphorylation and that this may constitute a threshold for the triggering of migraine attacks.
我们描述了31磷磁共振波谱法，并回顾了将其应用于偏头痛患者脑和肌肉能量代谢研究时的结果。在发作期间和发作间期进行测量时，偏头痛的所有主要亚型中脑能量代谢似乎均存在异常。骨骼肌中也有能量代谢受损的记录。我们认为偏头痛与线粒体氧化磷酸化的全身性紊乱有关，这可能构成触发偏头痛发作的一个阈值。
