Solliway B M, Schaffer A, Pratt H, Mittelman N, Yannai S
Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa.
J Neurol Sci. 1995 Dec;134(1-2):89-94. doi: 10.1016/0022-510x(95)00219-x.
Pattern reversal visual evoked potentials were recorded from 31 subjects who were occupationally exposed to lead and 54 non-exposed controls. No significant effects of lead were observed in the general subject population. However, when only non-smokers (17 lead-exposed and 27 controls) were evaluated, significant effects were found. The P100, but not the N75, latency was significantly prolonged in the lead-exposed group, and this correlated with both blood lead level and age. Nevertheless, both the N75 and P100 latencies correlated with the concentration of delta-aminolevulinic acid (delta-ALA) in urine and age. This, at least in part, could be due to elevated delta-ALA levels competing at gamma-aminobutyric acid (GABA) receptor neurons. This is consistent with the fact that GABA receptor neurons are involved along the entire length of the visual pathway. The results indicate that lead affects neural function even at permitted levels of exposure, and that this level should be reduced.
对31名职业性接触铅的受试者和54名未接触铅的对照者记录了图形翻转视觉诱发电位。在总体受试者群体中未观察到铅的显著影响。然而，当仅评估不吸烟者（17名接触铅者和27名对照者）时，发现了显著影响。在接触铅的组中，P100潜伏期显著延长，而N75潜伏期未延长，且这与血铅水平和年龄均相关。然而，N75和P100潜伏期均与尿中δ-氨基乙酰丙酸（δ-ALA）浓度和年龄相关。这至少部分可能是由于δ-ALA水平升高在γ-氨基丁酸（GABA）受体神经元处产生竞争所致。这与GABA受体神经元沿视觉通路全程均有涉及这一事实相一致。结果表明，即使在允许的接触水平下，铅也会影响神经功能，且该接触水平应降低。
