Weddle O H, Mason W D
J Pharm Sci. 1977 Jun;66(6):874-5. doi: 10.1002/jps.2600660637.
A rapid, specific, high-pressure liquid chromatographic method for the determination of procainamide and its N-acetyl derivative in plasma was developed. The procedure is fast enough (15 min from receipt of blood to reporting value) to be used for emergency determinations. The sensitivity, precision, and accuracy are sufficient for routine monitoring of therapeutic levels in patients. The assay is specific enough to be valid in the presence of a number of drugs and dietary substances present in clinical samples.
建立了一种快速、特异的高压液相色谱法，用于测定血浆中的普鲁卡因酰胺及其N - 乙酰衍生物。该方法速度足够快（从收到血样到报告结果只需15分钟），可用于紧急检测。其灵敏度、精密度和准确度足以用于患者治疗水平的常规监测。该测定法特异性足够强，在临床样本中存在多种药物和饮食物质的情况下仍有效。
