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焦虑的灵长类动物模型。纵向视角。

Primate models of anxiety. Longitudinal perspectives.

作者信息

Coplan J D, Rosenblum L A, Gorman J M

机构信息

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA.

出版信息

Psychiatr Clin North Am. 1995 Dec;18(4):727-43.

PMID:8748378
Abstract

In summary, VFD subjects appear to have sustained long-term behavioral and biologic sequelae following disruption of normative maternal-infant attachment patterns. The sequelae are primarily manifest as stable anxiety or affective traits and, from a biologic perspective, are most analogous to recent data that have emerged from studies of patients with PTSD. Multiple abnormalities are observed of systems directly involved in affect regulation. Further studies are required to clarify the pathologic ontogeny of the VFD condition and its potential relevance to human psychopathology.

摘要

总之,在规范的母婴依恋模式受到破坏后,VFD受试者似乎出现了长期的行为和生物学后遗症。这些后遗症主要表现为稳定的焦虑或情感特质,从生物学角度来看,与近期创伤后应激障碍(PTSD)患者研究中出现的数据最为相似。在直接参与情感调节的系统中观察到多种异常情况。需要进一步的研究来阐明VFD病症的病理发生过程及其与人类精神病理学的潜在关联。

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