Parrott R F, Ebenezer I S, Baldwin B A, Buttle H L
Babraham Institute, Cambridge.
Methods Find Exp Clin Pharmacol. 1995 Oct;17(8):529-33.
Blood samples were taken from prepubertal pigs (n = 7) surgically prepared with venous catheters before, and at intervals during the 30 min period after, administration of physiological saline (vehicle) or sulphated cholecystokinin octapeptide (CCK) (0.3, 0.7 and 1.3 mu g/kg). Plasma concentrations of prolactin and growth hormone were measured by radioimmunoassay. Statistically significant dose-related increases in prolactin occurred mainly in the first 10-min period following CCK administration. The peptide also stimulated growth hormone secretion although in a less consistent manner, with the increases tending to occur over a longer time period. Together with earlier reports showing that CCK induces cortisol release in pigs, these results suggest that the peptide's effect on anterior pituitary function could be indicative of a stress response.
在给青春期前的猪（n = 7）通过手术植入静脉导管后，在给予生理盐水（载体）或硫酸化胆囊收缩素八肽（CCK）（0.3、0.7和1.3μg/kg）之前以及给药后30分钟内的不同时间点采集血样。通过放射免疫分析法测定血浆中催乳素和生长激素的浓度。催乳素的统计学显著剂量相关增加主要发生在CCK给药后的第一个10分钟内。该肽也刺激生长激素分泌，尽管方式不太一致，增加趋势往往发生在更长的时间段内。连同早期显示CCK诱导猪皮质醇释放的报告，这些结果表明该肽对垂体前叶功能的影响可能指示应激反应。
