Rebok G W, Bylsma F W, Keyl P M, Brandt J, Folstein S E
Department of Mental Hygiene, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA.
Mov Disord. 1995 Nov;10(6):778-87. doi: 10.1002/mds.870100611.
We assessed the influence of the neurological and cognitive impairments of Huntington's disease (HD) on automobile driving. In a group of 73 HD outpatients, 53 (72%) continued to drive after illness onset. Those no longer driving had more severe symptoms than those still driving. Twenty-nine HD patients who were still driving and 16 healthy control subjects underwent a clinical examination, a cognitive examination, a driving-simulator assessment, and completed questionnaires about driving history and habits. HD patients performed significantly worse than control subjects on the driving-simulator tasks and were more likely to have been involved in a collision in the preceding 2 years (58% of HD vs. 11% of control subjects). Patients with collisions were less functionally impaired but had slower simple reaction time scores than did those without collisions. HD patients are at increased risk for accidents, but patients who have accidents are not easily distinguished from those who do not.
我们评估了亨廷顿舞蹈症（HD）的神经和认知障碍对汽车驾驶的影响。在一组73名HD门诊患者中，53名（72%）在发病后仍继续开车。不再开车的患者比仍在开车的患者症状更严重。29名仍在开车的HD患者和16名健康对照者接受了临床检查、认知检查、驾驶模拟器评估，并填写了关于驾驶历史和习惯的问卷。在驾驶模拟器任务中，HD患者的表现明显比对照者差，并且在之前两年内更有可能发生碰撞（HD患者为58%，对照者为11%）。发生碰撞的患者功能受损较轻，但简单反应时间得分比未发生碰撞的患者要慢。HD患者发生事故的风险增加，但发生事故的患者与未发生事故的患者不易区分。
