Suzuki K, Ishida H, Sugimoto C, Taguchi Y, Matsuda H, Nosaka K, Someya Y, Kadowaki S, Seino Y
Department of Metabolism and Clinical Nutrition, Kyoto University, Japan.
Diabet Med. 1995 Dec;12(12):1092-6. doi: 10.1111/j.1464-5491.1995.tb00426.x.
In order to investigate the relationship between urinary excretion of sialic acid and the severity of diabetic microangiopathy, urinary levels of sialic acid were determined in patients with non-insulin-dependent diabetes mellitus. The urinary molar ratio of sialic acid to creatinine in the diabetic patients was significantly higher than in the healthy controls (p < 0.01). Moreover, the urinary ratio was found to be gradually increased with the degree of diabetic microangiopathy. Urine molar ratio of sialic acid to creatinine in patients with proliferative diabetic retinopathy was significantly higher than in patients without retinopathy (p < 0.01). Urinary excretion in patients with macroproteinuria was also significantly higher than in patients without nephropathy (p < 0.01). Since urinary levels of sialic acid are proportionally increased with the severity of diabetic microangiopathy, the measurement of urinary sialic acid could become a useful biochemical means to monitor the degree of diabetic microangiopathy.
为了研究唾液酸的尿排泄与糖尿病微血管病变严重程度之间的关系，我们测定了非胰岛素依赖型糖尿病患者的尿唾液酸水平。糖尿病患者尿中唾液酸与肌酐的摩尔比显著高于健康对照组（p < 0.01）。此外，发现该尿比值随着糖尿病微血管病变程度的加重而逐渐升高。增殖性糖尿病视网膜病变患者尿中唾液酸与肌酐的摩尔比显著高于无视网膜病变的患者（p < 0.01）。大量蛋白尿患者的尿排泄量也显著高于无肾病的患者（p < 0.01）。由于尿唾液酸水平随糖尿病微血管病变严重程度成比例增加，因此测定尿唾液酸可能成为监测糖尿病微血管病变程度的一种有用的生化手段。
