Watanabe T, Negishi K, Katayama S, Ishii J, Kawazu S
Department of Medicine, Ogawa Red Cross Hospital, Saitama, Japan.
J Diabet Complications. 1991 Apr-Sep;5(2-3):191-2. doi: 10.1016/0891-6632(91)90070-6.
Concentrations of serum or urinary type IV collagen, determined by sandwich enzyme immunoassay, were significantly elevated in diabetics compared to controls (P less than .01). Serum or urinary levels of type IV collagen were significantly increased in patients with microangiopathy compared to those without microvascular disease (P less than .05). Serum type IV collagen levels were also augmented in diabetics who showed an increased albumin index for 1 year. Serum levels of type IV collagen were not affected by any conditions of metabolic control. The measurement of serum or urinary type IV collagen may be a useful indicator for monitoring the development of diabetic microangiopathy, especially in early diabetic nephropathy.
通过夹心酶免疫测定法测定的血清或尿IV型胶原蛋白浓度，与对照组相比，糖尿病患者显著升高（P<0.01）。与无微血管疾病的患者相比，微血管病变患者的血清或尿IV型胶原蛋白水平显著升高（P<0.05）。白蛋白指数升高1年的糖尿病患者血清IV型胶原蛋白水平也升高。血清IV型胶原蛋白水平不受任何代谢控制状况的影响。血清或尿IV型胶原蛋白的检测可能是监测糖尿病微血管病变发展的有用指标，尤其是在早期糖尿病肾病中。
