D'Ercole C, Boubli L, Franck J, Casta M, Harle J R, Chagnon C, Cravello L, Leclaire M, Blanc B
Service de Gynécologie-Obstétrique B, Hôpital de la Conception, Marseille, France.
Prenat Diagn. 1995 Dec;15(12):1171-5. doi: 10.1002/pd.1970151216.
We describe the case of a patient with systemic lupus erythematosus, treated by corticosteroids, who presented during two successive pregnancies with serological reactivation of toxoplasmosis associated with fetal lesions. The first infected fetus died in utero with signs of hydrops. The second fetus was treated in utero with a combination of sulfadoxine and pyrimethamine, administered to the mother, and is now well. The increasing number of immunocompromised pregnant patients with immunity to Toxoplasma gondii may lead to a higher risk of reactivation of maternal toxoplasmosis and congenital infection.
我们描述了一例系统性红斑狼疮患者的病例，该患者接受了皮质类固醇治疗，在连续两次怀孕期间出现弓形虫血清学再激活，并伴有胎儿病变。第一个受感染的胎儿在子宫内死亡，有水肿迹象。第二个胎儿在子宫内接受了母亲服用的磺胺多辛和乙胺嘧啶联合治疗，现在情况良好。对弓形虫具有免疫力的免疫功能低下孕妇数量不断增加，可能会导致母亲弓形虫病再激活和先天性感染的风险更高。
