Schallreuter-Wood K U, Pittelkow M R, Swanson N N
Department of Dermatology, University of Hamburg, Germany.
Arch Dermatol Res. 1996;288(1):11-3. doi: 10.1007/BF02505036.
Melanocytes were successfully established from involved and uninvolved skin of a patient with acute acrofacial vitiligo. Cells from involved epidermis showed a fivefold decrease in the rate of radiolabelled 45Ca uptake compared with uninvolved and control cells. These results are similar to previous findings in keratinocytes from involved skin in patients with vitiligo. Since 6-biopterin is cytotoxic to melanocytes and calcium controls the redox status of the 6-biopterin/(6R)5, 6, 7, 8-tetrahydrobiopterin equilibrium via the thioredoxin reductase/thioredoxin system, these results underline the importance of this electron transfer system for both melanocyte function and survival.
从一名急性肢端面部白癜风患者的受累皮肤和未受累皮肤中成功分离出黑素细胞。与未受累皮肤细胞及对照细胞相比，来自受累表皮的细胞对放射性标记的45Ca摄取率降低了五倍。这些结果与之前白癜风患者受累皮肤角质形成细胞的研究结果相似。由于6-生物蝶呤对黑素细胞具有细胞毒性，而钙通过硫氧还蛋白还原酶/硫氧还蛋白系统控制6-生物蝶呤/(6R)5, 6, 7, 8-四氢生物蝶呤平衡的氧化还原状态，这些结果强调了该电子传递系统对黑素细胞功能和存活的重要性。
