Koper N P, Kiemeney L A, Massuger L F, Thomas C M, Schijf C P, Verbeek A L
Department of Obstetrics and Gynecology, University Hospital Nijmegen, The Netherlands.
Obstet Gynecol. 1996 Sep;88(3):387-93. doi: 10.1016/0029-7844(96)00198-6.
To examine ovarian cancer incidence and mortality in the Netherlands, and to relate trends in mortality to changes in parity and use of oral contraceptives.
Age-standardized and age-specific incidence and mortality rates are presented using incidence data from the Netherlands Cancer Registry, 1989-1991, and mortality data from the Netherlands Central Bureau of Statistics, 1954-1993.
In the period 1989-1991, age-standardized incidence of ovarian cancer was 14.9 per 10(5) woman-years. The majority (89%) of these tumors had an epithelial origin. Two-thirds of all newly diagnosed ovarian cancers already showed extension to the pelvis or beyond at diagnosis. From the period 1954-1958 to 1969-1973, age-standardized mortality rates increased from 10.6 to 13.1 per 10(5) woman-years. Thereafter, a decline was noted to 11.4 per 10(5) woman-years in the period 1989-1993. Age-specific mortality rates showed a pattern of rising mortality in the elderly, whereas mortality in the younger age categories was declining. The number of live births has declined gradually, and oral contraceptive use has increased.
Incidence of ovarian cancer is high in the Netherlands, but comparable to other countries in north-western Europe and North America. Mortality rates are rising in the elderly and declining in the young. Further research is needed concerning the effects of oral contraceptives, fertility drugs, and hormone replacement therapy on the incidence and mortality of ovarian cancer.
研究荷兰卵巢癌的发病率和死亡率，并将死亡率趋势与生育状况及口服避孕药使用情况的变化相关联。
采用1989 - 1991年荷兰癌症登记处的发病率数据以及1954 - 1993年荷兰中央统计局的死亡率数据，呈现年龄标准化发病率和年龄别发病率及死亡率。
1989 - 1991年期间，卵巢癌年龄标准化发病率为每10⁵女性年14.9例。这些肿瘤大多数（89%）起源于上皮组织。所有新诊断的卵巢癌中，三分之二在诊断时已显示肿瘤扩散至盆腔或盆腔以外。从1954 - 1958年到1969 - 1973年，年龄标准化死亡率从每10⁵女性年10.6例增至13.1例。此后，在1989 - 1993年期间降至每10⁵女性年11.4例。年龄别死亡率显示老年人死亡率上升，而较年轻年龄组死亡率下降。活产数逐渐减少，口服避孕药的使用增加。
荷兰卵巢癌发病率较高，但与西北欧其他国家和北美相当。老年人死亡率上升，年轻人死亡率下降。关于口服避孕药、生育药物和激素替代疗法对卵巢癌发病率和死亡率的影响，还需要进一步研究。
