Ryan M J, Ramsay M, Brown D, Gay N J, Farrington C P, Wall P G
Communicable Disease Surveillance Centre, London, United Kingdom.
J Infect Dis. 1996 Sep;174 Suppl 1:S12-8. doi: 10.1093/infdis/174.supplement_1.s12.
Laboratory reports and data on hospital admissions were used to estimate the number of hospitalizations due to group A rotavirus infection in England and Wales. Between January 1990 and December 1994, there were 75,059 laboratory reports of rotavirus infection, and 66,062 of these were in children <5 years old; rotavirus represented 39% of all pathogens identified in fecal specimens from this age group. Between April 1993 and March 1994, 1904 hospital admissions coded as "infectious intestinal disease" and 2354 coded as "noninfective gastroenteritis" occurred in children <5 in the North Thames region (a health authority representing 13% of the population in England and Wales). By modeling admission and laboratory reporting data, it was estimated that 54% of hospitalizations for intestinal infectious disease and 34% for noninfective gastroenteritis were attributable to rotavirus. By extrapolation of the North Thames data, it was estimated that 17,810 rotavirus-related hospitalizations (5/1000 children <5 years old) occurred in England and Wales during the same period. Effective vaccines have the potential to substantially reduce the number of hospital admissions due to group A rotavirus infection.
实验室报告和医院入院数据被用于估算英格兰和威尔士因A组轮状病毒感染导致的住院人数。1990年1月至1994年12月期间，有75059份轮状病毒感染的实验室报告，其中66062份是5岁以下儿童的报告；轮状病毒占该年龄组粪便标本中鉴定出的所有病原体的39%。1993年4月至1994年3月期间，北泰晤士地区（一个代表英格兰和威尔士13%人口的卫生当局）5岁以下儿童中有1904例住院病例被编码为“感染性肠道疾病”，2354例被编码为“非感染性肠胃炎”。通过对入院和实验室报告数据进行建模，估计肠道传染病住院病例的54%和非感染性肠胃炎住院病例的34%可归因于轮状病毒。通过对北泰晤士地区数据进行推断，估计同期英格兰和威尔士有17810例与轮状病毒相关的住院病例（每1000名5岁以下儿童中有5例）。有效的疫苗有可能大幅减少因A组轮状病毒感染导致的住院人数。
