Field Epidemiology Training Programme, Public Health England, London, UK.
Public Health England, London, UK.
Influenza Other Respir Viruses. 2022 Jan;16(1):125-131. doi: 10.1111/irv.12910. Epub 2021 Oct 17.
Respiratory syncytial virus (RSV) is a common seasonal respiratory virus and an important cause of illness among infants, but the burden of RSV disease is not well described among the older population. The objective of this study was to estimate the age-specific incidence of hospital admission among over 65 s due to respiratory illnesses attributable to RSV in England to inform optimal vaccine and therapeutic interventions. We used linear multiple regression to examine the effect of changes in weekly counts of respiratory pathogens on the weekly counts of respiratory hospital admissions. The study population was all patients aged 65 years or over admitted to English hospitals between 2nd August 2010 and 30th July 2017. RSV was estimated to account for a seasonal annual average of 71 (95% CI 52-90) respiratory admissions per 100 000 in adults age 65-74 and 251 (95% CI 186-316) admissions per 100,000 adults age 75+. Pneumococcus was the pathogen responsible for highest annual average respiratory admission with 448 (95% CI 310-587) admissions per 100,000 adults age 65-74 and 1010 (95% CI 527-1493) admissions per 100,000 adults aged 75+. This study shows that RSV continues to exert a significant burden of disease among older adults in England. These findings will support development of policy for the use of RSV therapeutics and vaccines in this age group.
呼吸道合胞病毒（RSV）是一种常见的季节性呼吸道病毒，也是婴儿患病的重要原因，但老年人中 RSV 疾病的负担情况描述得并不充分。本研究的目的是估计英格兰 65 岁以上人群因 RSV 引起的呼吸道疾病而住院的特定年龄发病率，为优化 RSV 疫苗和治疗干预措施提供信息。我们使用线性多重回归来研究每周呼吸道病原体数量变化对每周呼吸道住院人数的影响。研究人群为 2010 年 8 月 2 日至 2017 年 7 月 30 日期间在英格兰医院住院的所有 65 岁或以上的患者。RSV 估计每年平均导致每 100,000 名 65-74 岁成人中有 71 例（95%CI 52-90）呼吸道疾病住院，每 100,000 名 75 岁以上成人中有 251 例（95%CI 186-316）呼吸道疾病住院。肺炎球菌是导致每年平均呼吸道住院人数最高的病原体，每 100,000 名 65-74 岁成人中有 448 例（95%CI 310-587），每 100,000 名 75 岁以上成人中有 1010 例（95%CI 527-1493）。本研究表明，RSV 继续给英格兰的老年人群带来重大疾病负担。这些发现将支持制定该年龄组使用 RSV 治疗药物和疫苗的政策。
