Washimi Y, Saitou K
Department of Neurology Nagoya Ekisaikai Hospital.
Rinsho Shinkeigaku. 1995 Dec;35(12):1525-7.
The gradient of negative slope (Ns') changed in parallel with the velocity of step movement in normal individuals. We can not evaluate the MRCPs without considering this factor among patients and/or subjects. We recorded the MRCPs of thirty nine patients with cerebellar ataxias and sixteen patients with Parkinson disease (PD). Goniometer was attached on the patient's wrist to measure the velocity of the wrist movement. In the patients with spinocerebellar degeneration with denate nucleus lesion (Machado-Joseph disease, DRPLA, MERRF, dyssynergia cerebellaris myoclonica, galactosialidosis), the gradients of Ns' were reduced, although the movements themselves were as fast as normal control. In the patients with spinocerebellar degeneration without this lesion, the MRCPs were able to record as normal control, and their gradients of Ns' became steeper according to the increase of the movement angular velocity. On the contrary, in the patients with Parkinson disease, the gradients of Ns' were steeper in the patients with slow movement than in those with fast movement. The MRCP helps us to investigate the pathophysiology of the movement disorders. It is desirable that physiological data on the MRCP are extensively accumulated.
在正常个体中，负斜率梯度（Ns'）随步行动作速度平行变化。在患者和/或受试者中，如果不考虑这个因素，我们就无法评估运动反应时程（MRCPs）。我们记录了39例小脑共济失调患者和16例帕金森病（PD）患者的运动反应时程。在患者手腕上附着测角仪以测量手腕运动速度。在伴有齿状核病变的脊髓小脑变性患者（马查多-约瑟夫病、齿状核红核苍白球路易体萎缩症、肌阵挛性癫痫伴破碎红纤维综合征、肌阵挛性小脑协同失调、涎酸贮积症）中，尽管其动作本身与正常对照一样快，但Ns'的梯度降低。在无此病变的脊髓小脑变性患者中，运动反应时程能够像正常对照一样记录下来，并且随着运动角速度的增加，其Ns'的梯度变得更陡。相反，在帕金森病患者中，动作缓慢的患者Ns'的梯度比动作快速的患者更陡。运动反应时程有助于我们研究运动障碍的病理生理学。广泛积累关于运动反应时程的生理数据是很有必要的。
