Barrera J M, Bruguera M, González M, Gálvez A, Castillo R, Rodés J
Servicio de Hepatología, Hospital Clinic i Provincial, Universidad de Barcelona.
Gastroenterol Hepatol. 1996 May;19(5):240-2.
To assess the efficacy of blood donor screening with a second generation ELISA for the detection of anti HCV the incidence of post transfusion hepatitis was prospectively determined in 190 patients submitted to cardiovascular surgery. An increase greater than 100 U/l of transaminases of serum activity was detected in five patients (2.6%), being found in four patients at 3 months of the transfusion and in one patient at 6 months. Serologic markers for HAV, HBV, HCV, CMV and EBV were not identified in any of these cases of post transfusion hepatitis and it is therefore assumed that they may have been caused by an, as yet unidentified, agent. It is concluded that second generation ELISA screening for anti HCV is very effective in the prevention of post transfusion hepatitis C.
为评估采用第二代酶联免疫吸附测定法（ELISA）筛查献血者以检测抗丙型肝炎病毒（抗HCV）的效果，前瞻性地确定了190例接受心血管手术患者的输血后肝炎发病率。5例患者（2.6%）血清转氨酶活性升高超过100 U/l，其中4例在输血后3个月发现，1例在输血后6个月发现。在这些输血后肝炎病例中均未检测到甲型肝炎病毒（HAV）、乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、巨细胞病毒（CMV）和EB病毒（EBV）的血清学标志物，因此推测它们可能是由一种尚未明确的病原体引起的。得出的结论是，第二代ELISA法筛查抗HCV在预防输血后丙型肝炎方面非常有效。
