Chanez P, Enander I, Jones I, Godard P, Bousquet J
Clinique des Maladies Respiratoires, Hôpital Arnaud-de-Villeneuve, Montpellier, France.
Int Arch Allergy Immunol. 1996 Sep;111(1):83-8. doi: 10.1159/000237350.
Interleukin 8 (IL-8) is a chemoattractant cytokine having a distinct target specificity for the neutrophil. However, it was also found to be active on primed eosinophils. IL-8 was measured by enzyme immunoassay in the bronchoalveolar lavage fluid (BALF) of 9 control subjects, 19 asthmatics and 36 chronic bronchitis patients. Its levels were correlated with neutrophil and eosinophil counts as well as levels of myeloperoxidase (MPO) and eosinophil cationic protein in the BALF. Asthmatic and chronic bronchitis patients had elevated levels of IL-8 in comparison with normal subjects. There was no correlation between the severity of asthma or chronic bronchitis and IL-8 levels. In asthmatic subjects there was a correlation between IL-8 and MPO levels (p < 0.0001, Spearman test). There was no significant correlation between eosinophils and IL-8. In chronic bronchitis there was a correlation between IL-8 and MPO levels as well as between IL-8 and neutrophil counts (p < 0.004 and p < 0.0152, respectively, Spearman test). IL-8 is involved in neutrophilic inflammation in asthma and chronic bronchitis, but differences in the IL-8 regulation of neutrophils were observed in both diseases.
白细胞介素8（IL-8）是一种对中性粒细胞具有独特靶标特异性的趋化因子细胞因子。然而，人们还发现它对致敏嗜酸性粒细胞也有活性。通过酶免疫测定法对9名对照受试者、19名哮喘患者和36名慢性支气管炎患者的支气管肺泡灌洗液（BALF）中的IL-8进行了测量。其水平与BALF中的中性粒细胞和嗜酸性粒细胞计数以及髓过氧化物酶（MPO）和嗜酸性粒细胞阳离子蛋白水平相关。与正常受试者相比，哮喘患者和慢性支气管炎患者的IL-8水平升高。哮喘或慢性支气管炎的严重程度与IL-8水平之间没有相关性。在哮喘患者中，IL-8与MPO水平之间存在相关性（p < 0.0001，Spearman检验）。嗜酸性粒细胞与IL-8之间没有显著相关性。在慢性支气管炎中，IL-8与MPO水平以及IL-8与中性粒细胞计数之间存在相关性（分别为p < 0.004和p < 0.0152，Spearman检验）。IL-8参与哮喘和慢性支气管炎中的嗜中性粒细胞炎症，但在这两种疾病中观察到IL-8对中性粒细胞的调节存在差异。
