Uranova N A
Vestn Ross Akad Med Nauk. 1996(4):23-9.
A qualitative and quantitative electron microscopic study was performed. in some postmortem brain structures of the dopaminergic system: the substantia nigra, ventral tegmentum area, prefrontal cortex (area 10), anterior cingulate cortex (area 24), the head of the caudate nucleus in schizophrenia and age-matched controls without mental disorders. The study revealed the heterogeneity of ultrastructural changes in synaptic ultrastructure and organization in schizophrenia as compared to controls. There was an anomalous sprouting of axons and a trend to increase the numerical density of axospinous synapses and to decrease axodendritic synapses in the schizophrenic brains due to disontogenesis or anomalous synaptic plasticity. No correlations with neuroleptic treatment were found. Synaptic plasticity might be involved in the pathophysiology and clinical symptoms of schizophrenic patients.
对精神分裂症患者及年龄匹配的无精神障碍对照者的多巴胺能系统的一些死后脑结构进行了定性和定量电子显微镜研究，这些脑结构包括黑质、腹侧被盖区、前额叶皮质（10区）、前扣带回皮质（24区）、尾状核头部。研究发现，与对照组相比，精神分裂症患者突触超微结构和组织的超微结构变化具有异质性。由于发育异常或异常的突触可塑性，精神分裂症患者大脑中存在轴突异常发芽，轴棘突触的数值密度有增加趋势，轴树突突触有减少趋势。未发现与抗精神病药物治疗有相关性。突触可塑性可能参与了精神分裂症患者的病理生理学和临床症状。
