不同年龄大鼠分离的肝细胞的呼吸活动。简短报告。
Respiratory activities of hepatocytes isolated from rats of various ages. A brief note.
作者信息
Brouwer A, Van Bezooijen C F, Knook D L
出版信息
Mech Ageing Dev. 1977 Jul-Aug;6(4):265-9. doi: 10.1016/0047-6374(77)90027-6.
PMID:875487
Abstract
The ratio between the oxygen consumption of isolated hepatocytes in the presence of an inhibitor of oxidative phosphorylation (oligomycin, atractyloside) and in the presence of an uncoupler (dinitrophenol) is used as an estimation of the respiratory control ratio of mitochondria inside the isolated liver parenchymal cell. No significant age-related decline in the functional integrity of the mitochondria could be detected.
摘要
在存在氧化磷酸化抑制剂（寡霉素、苍术苷）和存在解偶联剂（二硝基苯酚）的情况下，分离的肝细胞的耗氧率之比，被用作对分离的肝实质细胞内线粒体呼吸控制率的一种估算。未检测到线粒体功能完整性存在与年龄相关的显著下降。
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