Gale Nicholas W, Holland Sacha J, Valenzuela David M, Flenniken Ann, Pan Li, Ryan Terence E, Henkemeyer Mark, Strebhardt Klaus, Hirai Hisamaru, Wilkinson David G, Pawson Tony, Davis Samuel, Yancopoulos George D
Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York, 10591-6707, USA.
Neuron. 1996 Jul;17(1):9-19. doi: 10.1016/s0896-6273(00)80276-7.
We report that the many Eph-related receptor tyrosine kinases, and their numerous membrane-bound ligands, can each be grouped into only two major specificity subclasses. Receptors in a given subclass bind most members of a corresponding ligand subclass. The physiological relevance of these groupings is suggested by viewing the collective distributions of all members of a subclass. These composite distributions, in contrast with less informative patterns seen with individual members of the family, reveal that the developing embryo is subdivided into domains defined by reciprocal and apparently mutually exclusive expression of a receptor subclass and its corresponding ligands. Receptors seem to encounter their ligands only at the interface between these domains. This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan.
我们报告称，众多与Eph相关的受体酪氨酸激酶及其众多膜结合配体，各自仅能被归入两个主要的特异性亚类。给定亚类中的受体与相应配体亚类的大多数成员结合。通过观察一个亚类所有成员的总体分布，提示了这些分组的生理相关性。与该家族单个成员所见的信息量较少的模式相比，这些复合分布表明，发育中的胚胎被细分为由受体亚类及其相应配体的相互且明显相互排斥的表达所定义的区域。受体似乎仅在这些区域之间的界面处遇到其配体。这种相互的分隔意味着Eph家族参与了可能有助于组织发育中的身体蓝图的空间边界的形成。
