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EVALUATION OF A RECENTLY REPORTED STABLE LIEBERMANN-BURCHARD REAGENT AND ITS USE FOR THE DIRECT DETERMINATION OF SERUM TOTAL CHOLESTEROL.一种新近报道的稳定的利伯曼-布赫哈德试剂的评估及其用于直接测定血清总胆固醇的应用
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Specific accumulation of lipoprotein(a) in balloon-injured rabbit aorta in vivo.脂蛋白(a)在体内球囊损伤兔主动脉中的特异性蓄积。
Circ Res. 1996 Apr;78(4):615-26. doi: 10.1161/01.res.78.4.615.
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Proliferation of human smooth muscle cells promoted by lipoprotein(a).脂蛋白(a)促进人平滑肌细胞增殖。
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Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation.巨噬细胞的胆固醇负载导致天然脂蛋白(a)和载脂蛋白(a)内化及降解显著增强。
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Influx, efflux, and accumulation of LDL in normal arterial areas and atherosclerotic lesions of white Carneau pigeons with naturally occurring and cholesterol-aggravated aortic atherosclerosis.患有自然发生和胆固醇加重型主动脉粥样硬化的白卡诺鸽正常动脉区域和动脉粥样硬化病变中低密度脂蛋白的流入、流出和蓄积情况。
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Glycosaminoglycan fractions from human arteries presenting diverse susceptibilities to atherosclerosis have different binding affinities to plasma LDL.对动脉粥样硬化具有不同易感性的人动脉中的糖胺聚糖组分对血浆低密度脂蛋白具有不同的结合亲和力。
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Lipoprotein(a) and its role in atherothrombotic disease.脂蛋白(a)及其在动脉粥样硬化血栓形成性疾病中的作用。
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The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate.血浆脂蛋白(a)浓度与载脂蛋白(a)异构体大小的负相关并非由于脂蛋白(a)分解代谢的差异，而是由于生成速率的差异。
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Polymorphic forms of Lp(a) with different structural and functional properties: cold-induced self-association and binding to fibrin and lysine-Sepharose.具有不同结构和功能特性的Lp(a)多态形式：冷诱导的自缔合以及与纤维蛋白和赖氨酸-琼脂糖的结合
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与无病变的兔主动脉相比，脂蛋白(a)在动脉粥样硬化兔主动脉中优先流入且分数丢失减少。

Preferential influx and decreased fractional loss of lipoprotein(a) in atherosclerotic compared with nonlesioned rabbit aorta.

作者信息

Nielsen L B, Stender S, Jauhiainen M, Nordestgaard B G

机构信息

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.

出版信息

J Clin Invest. 1996 Jul 15;98(2):563-71. doi: 10.1172/JCI118824.

DOI:10.1172/JCI118824
PMID:8755669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC507462/
Abstract

The aim was to investigate the atherogenic potential of lipoprotein(a) (Lp(a)) and to further our understanding of the atherogenic process by measuring rates of transfer into the intima-inner media (i.e., intimal clearance) and rates of loss from the intima-inner media (i.e., fractional loss) of Lp(a) and LDL using cholesterol-fed rabbits with nonlesioned (n = 13) or atherosclerotic aortas (n = 12). In each rabbit, 131I-Lp(a) (or 131I-LDL) was injected intravenously 26 h before and 125I-Lp(a) (or 125I-LDL) 3 h before the aorta was removed and divided into six consecutive segments of similar size. The intimal clearance of Lp(a) and LDL was similar and markedly increased in atherosclerotic compared with nonlesioned aortas (ANOVA, effect of atherosclerosis: P < 0.0001). Fractional losses of labeled Lp(a) and labeled LDL in atherosclerotic aorta were on average 25 and 43%, respectively, of that in nonlesioned aortas (ANOVA, effect of atherosclerosis: P < 0.0001). Fractional loss of Lp(a) was 73% of that of LDL (ANOVA, effect of type of lipoprotein: P = 0.07). These data suggest that the development of atherosclerosis is associated with increased influx as well as decreased fractional loss of Lp(a) and LDL from the intima. Accordingly, Lp(a) may share with LDL the potential for causing atherosclerosis.

摘要

目的是研究脂蛋白(a)[Lp(a)]的致动脉粥样硬化潜力，并通过测量Lp(a)和低密度脂蛋白(LDL)进入内膜-内中膜的速率（即内膜清除率）以及从内膜-内中膜的丢失速率（即分数丢失率），来加深我们对动脉粥样硬化形成过程的理解，研究采用喂食胆固醇的家兔，其主动脉无病变（n = 13）或有动脉粥样硬化（n = 12）。在每只家兔中，在取出主动脉并将其分成六个大小相似的连续节段前26小时静脉注射131I-Lp(a)（或131I-LDL），3小时前注射125I-Lp(a)（或125I-LDL）。与无病变的主动脉相比，Lp(a)和LDL的内膜清除率相似，且在动脉粥样硬化的主动脉中显著增加（方差分析，动脉粥样硬化的影响：P < 0.0001）。在动脉粥样硬化主动脉中，标记的Lp(a)和标记的LDL的分数丢失分别平均为无病变主动脉中的25%和43%（方差分析，动脉粥样硬化的影响：P < 0.0001）。Lp(a)的分数丢失是LDL的73%（方差分析，脂蛋白类型的影响：P = 0.07）。这些数据表明，动脉粥样硬化的发展与Lp(a)和LDL从内膜的流入增加以及分数丢失减少有关。因此，Lp(a)可能与LDL一样具有致动脉粥样硬化潜力。