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与无病变的兔主动脉相比，脂蛋白(a)在动脉粥样硬化兔主动脉中优先流入且分数丢失减少。

Preferential influx and decreased fractional loss of lipoprotein(a) in atherosclerotic compared with nonlesioned rabbit aorta.

作者信息

Nielsen L B, Stender S, Jauhiainen M, Nordestgaard B G

机构信息

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.

出版信息

J Clin Invest. 1996 Jul 15;98(2):563-71. doi: 10.1172/JCI118824.

DOI:10.1172/JCI118824
PMID:8755669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC507462/
Abstract

The aim was to investigate the atherogenic potential of lipoprotein(a) (Lp(a)) and to further our understanding of the atherogenic process by measuring rates of transfer into the intima-inner media (i.e., intimal clearance) and rates of loss from the intima-inner media (i.e., fractional loss) of Lp(a) and LDL using cholesterol-fed rabbits with nonlesioned (n = 13) or atherosclerotic aortas (n = 12). In each rabbit, 131I-Lp(a) (or 131I-LDL) was injected intravenously 26 h before and 125I-Lp(a) (or 125I-LDL) 3 h before the aorta was removed and divided into six consecutive segments of similar size. The intimal clearance of Lp(a) and LDL was similar and markedly increased in atherosclerotic compared with nonlesioned aortas (ANOVA, effect of atherosclerosis: P < 0.0001). Fractional losses of labeled Lp(a) and labeled LDL in atherosclerotic aorta were on average 25 and 43%, respectively, of that in nonlesioned aortas (ANOVA, effect of atherosclerosis: P < 0.0001). Fractional loss of Lp(a) was 73% of that of LDL (ANOVA, effect of type of lipoprotein: P = 0.07). These data suggest that the development of atherosclerosis is associated with increased influx as well as decreased fractional loss of Lp(a) and LDL from the intima. Accordingly, Lp(a) may share with LDL the potential for causing atherosclerosis.

摘要

目的是研究脂蛋白(a)[Lp(a)]的致动脉粥样硬化潜力，并通过测量Lp(a)和低密度脂蛋白(LDL)进入内膜-内中膜的速率（即内膜清除率）以及从内膜-内中膜的丢失速率（即分数丢失率），来加深我们对动脉粥样硬化形成过程的理解，研究采用喂食胆固醇的家兔，其主动脉无病变（n = 13）或有动脉粥样硬化（n = 12）。在每只家兔中，在取出主动脉并将其分成六个大小相似的连续节段前26小时静脉注射131I-Lp(a)（或131I-LDL），3小时前注射125I-Lp(a)（或125I-LDL）。与无病变的主动脉相比，Lp(a)和LDL的内膜清除率相似，且在动脉粥样硬化的主动脉中显著增加（方差分析，动脉粥样硬化的影响：P < 0.0001）。在动脉粥样硬化主动脉中，标记的Lp(a)和标记的LDL的分数丢失分别平均为无病变主动脉中的25%和43%（方差分析，动脉粥样硬化的影响：P < 0.0001）。Lp(a)的分数丢失是LDL的73%（方差分析，脂蛋白类型的影响：P = 0.07）。这些数据表明，动脉粥样硬化的发展与Lp(a)和LDL从内膜的流入增加以及分数丢失减少有关。因此，Lp(a)可能与LDL一样具有致动脉粥样硬化潜力。

相似文献

[1]
Preferential influx and decreased fractional loss of lipoprotein(a) in atherosclerotic compared with nonlesioned rabbit aorta.

J Clin Invest. 1996-7-15

[2]
Increased degradation of lipoprotein(a) in atherosclerotic compared with nonlesioned aortic intima-inner media of rabbits: in vivo evidence that lipoprotein(a) may contribute to foam cell formation.

Arterioscler Thromb Vasc Biol. 1998-4

[3]
Transfer of lipoprotein(a) and LDL into aortic intima in normal and in cholesterol-fed rabbits.

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[4]
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[5]
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[6]
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[7]
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[8]
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[10]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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