葡萄糖阻遏可能涉及具有不同糖激酶需求的过程。
Glucose repression may involve processes with different sugar kinase requirements.
作者信息
Sanz P, Nieto A, Prieto J A
机构信息
Departmento de Biotecnología de Alimentos, Instituto de Agroquímica yTecnología de Alimentos, Consejo Superior de Investigaciones Cientificas, Valencia, Spain.
出版信息
J Bacteriol. 1996 Aug;178(15):4721-3. doi: 10.1128/jb.178.15.4721-4723.1996.
Abstract
Adding glucose to Saccharomyces cerevisiae cells growing among nonfermentable carbon sources leads to glucose repression. This process may be resolved into several steps. An early repression response requires any one of the three glucose kinases present in S. cerevisiae (HXK1, HXK2, or GLK1). A late response is only achieved when Hxk2p is present.
摘要
向在非发酵性碳源中生长的酿酒酵母细胞添加葡萄糖会导致葡萄糖阻遏。这个过程可分为几个步骤。早期阻遏反应需要酿酒酵母中存在的三种葡萄糖激酶中的任何一种（HXK1、HXK2或GLK1）。只有当Hxk2p存在时才会出现晚期反应。
相似文献
1
Glucose repression may involve processes with different sugar kinase requirements.葡萄糖阻遏可能涉及具有不同糖激酶需求的过程。
J Bacteriol. 1996 Aug;178(15):4721-3. doi: 10.1128/jb.178.15.4721-4723.1996.
2
The hexokinase 2 protein regulates the expression of the GLK1, HXK1 and HXK2 genes of Saccharomyces cerevisiae.己糖激酶2蛋白调节酿酒酵母的GLK1、HXK1和HXK2基因的表达。
Biochem J. 2001 May 1;355(Pt 3):625-31. doi: 10.1042/bj3550625.
3
Differential requirement of the yeast sugar kinases for sugar sensing in establishing the catabolite-repressed state.酵母糖激酶在建立分解代谢物阻遏状态时对糖感知的差异需求。
Eur J Biochem. 1996 Oct 15;241(2):633-43. doi: 10.1111/j.1432-1033.1996.00633.x.
4
Transcriptional regulation of the Saccharomyces cerevisiae HXK1, HXK2 and GLK1 genes.酿酒酵母HXK1、HXK2和GLK1基因的转录调控
Yeast. 1995 Feb;11(2):137-44. doi: 10.1002/yea.320110205.
5
Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources.酿酒酵母中葡萄糖触发的信号传导：在葡萄糖上生长的细胞与在非发酵碳源上生长的细胞之间对糖磷酸化的不同要求。
Microbiology (Reading). 1996 Jul;142 ( Pt 7):1775-82. doi: 10.1099/13500872-142-7-1775.
6
Functional characterization of transcriptional regulatory elements in the upstream region of the yeast GLK1 gene.酵母GLK1基因上游区域转录调控元件的功能特性分析
Biochem J. 1999 Oct 15;343 Pt 2(Pt 2):319-25.
7
Genetics of yeast glucokinase.酵母葡萄糖激酶的遗传学
Genetics. 1983 Nov;105(3):501-15. doi: 10.1093/genetics/105.3.501.
8
Mediator factor Med8p interacts with the hexokinase 2: implication in the glucose signalling pathway of Saccharomyces cerevisiae.介质因子Med8p与己糖激酶2相互作用：对酿酒酵母葡萄糖信号通路的影响。
J Mol Biol. 2002 Jun 7;319(3):703-14. doi: 10.1016/S0022-2836(02)00377-7.
9
Saccharomyces cerevisiae null mutants in glucose phosphorylation: metabolism and invertase expression.葡萄糖磷酸化过程中的酿酒酵母缺失突变体：代谢与转化酶表达
Genetics. 1991 Jul;128(3):521-7. doi: 10.1093/genetics/128.3.521.
10
Glucose controls multiple processes in Saccharomyces cerevisiae through diverse combinations of signaling pathways.葡萄糖通过多种信号通路组合控制酿酒酵母中的多个过程。
FEMS Yeast Res. 2007 Sep;7(6):808-18. doi: 10.1111/j.1567-1364.2007.00236.x. Epub 2007 Apr 12.
引用本文的文献
1
Mig1 localization exhibits biphasic behavior which is controlled by both metabolic and regulatory roles of the sugar kinases.Mig1 定位表现出双相行为，这种行为受到糖激酶的代谢和调节作用的控制。
Mol Genet Genomics. 2020 Nov;295(6):1489-1500. doi: 10.1007/s00438-020-01715-4. Epub 2020 Sep 19.
2
Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast.葡萄糖诱导酵母中蛋白磷酸酶 PP2A 和 PP1 的翻译后激活。
Cell Res. 2012 Jun;22(6):1058-77. doi: 10.1038/cr.2012.20. Epub 2012 Jan 31.
3
Regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae.连接酿酒酵母中两条葡萄糖信号转导途径的调控网络。
Eukaryot Cell. 2004 Feb;3(1):221-31. doi: 10.1128/EC.3.1.221-231.2004.
4
Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism.Snf1激酶的亚细胞定位受特定β亚基和一种新型葡萄糖信号传导机制的调控。
Genes Dev. 2001 May 1;15(9):1104-14. doi: 10.1101/gad.879301.
5
The Aspergillus nidulans xprF gene encodes a hexokinase-like protein involved in the regulation of extracellular proteases.构巢曲霉xprF基因编码一种参与细胞外蛋白酶调控的类己糖激酶蛋白。
Genetics. 2000 Dec;156(4):1559-71. doi: 10.1093/genetics/156.4.1559.
6
Structure-function analysis of yeast hexokinase: structural requirements for triggering cAMP signalling and catabolite repression.酵母己糖激酶的结构-功能分析：触发cAMP信号传导和分解代谢物阻遏的结构要求。
Biochem J. 1999 Oct 1;343 Pt 1(Pt 1):159-68.
7
Yeast carbon catabolite repression.酵母碳源分解代谢物阻遏
Microbiol Mol Biol Rev. 1998 Jun;62(2):334-61. doi: 10.1128/MMBR.62.2.334-361.1998.
8
A regulatory mutant of Hansenula polymorpha exhibiting methanol utilization metabolism and peroxisome proliferation in glucose.一种多形汉逊酵母的调控突变体，在葡萄糖中表现出甲醇利用代谢和过氧化物酶体增殖。
J Bacteriol. 1998 Jun;180(11):2958-67. doi: 10.1128/JB.180.11.2958-2967.1998.
9
Carbon source-dependent phosphorylation of hexokinase PII and its role in the glucose-signaling response in yeast.己糖激酶PII的碳源依赖性磷酸化及其在酵母葡萄糖信号应答中的作用。
Mol Cell Biol. 1998 May;18(5):2940-8. doi: 10.1128/MCB.18.5.2940.
本文引用的文献
1
2
The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast.一种特定的2-脱氧葡萄糖-6-磷酸磷酸酶的表达可防止酵母中由2-脱氧葡萄糖介导的分解代谢物阻遏。
Curr Genet. 1995 Jul;28(2):101-7. doi: 10.1007/BF00315774.
3
Lack of correlation between trehalase activation and trehalose-6 phosphate synthase deactivation in cAMP-altered mutants of Saccharomyces cerevisiae.酿酒酵母cAMP改变突变体中海藻糖酶激活与6-磷酸海藻糖合酶失活之间缺乏相关性。
Curr Genet. 1993 May-Jun;23(5-6):382-7. doi: 10.1007/BF00312622.
4
Glucose repression in fungi.真菌中的葡萄糖阻遏
Trends Genet. 1995 Jan;11(1):12-7. doi: 10.1016/s0168-9525(00)88980-5.
5
Trehalose synthase: guard to the gate of glycolysis in yeast?海藻糖合酶：酵母糖酵解之门的守护者？
Trends Biochem Sci. 1995 Jan;20(1):3-10. doi: 10.1016/s0968-0004(00)88938-0.
6
Carbon catabolite repression of maltase synthesis in Saccharomyces carlsbergensis.卡尔斯伯酵母中麦芽糖酶合成的碳分解代谢物阻遏
J Bacteriol. 1983 Oct;156(1):301-7. doi: 10.1128/jb.156.1.301-307.1983.
7
Transport of 6-deoxyglucose in Saccharomyces cerevisiae.酿酒酵母中6-脱氧葡萄糖的转运
J Bacteriol. 1983 Sep;155(3):995-1000. doi: 10.1128/jb.155.3.995-1000.1983.
8
The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae.己糖激酶II突变体的残余酶促磷酸化活性与酿酒酵母中的葡萄糖阻遏相关。
Mol Cell Biol. 1989 Dec;9(12):5643-9. doi: 10.1128/mcb.9.12.5643-5649.1989.
9
Structure and regulation of the multigene family controlling maltose fermentation in budding yeast.
Prog Nucleic Acid Res Mol Biol. 1989;37:281-322. doi: 10.1016/s0079-6603(08)60701-1.
10
Extragenic suppressors of yeast glucose derepression mutants leading to constitutive synthesis of several glucose-repressible enzymes.酵母葡萄糖去阻遏突变体的基因外抑制子，导致几种葡萄糖可阻遏酶的组成型合成。
J Bacteriol. 1991 Mar;173(6):2045-52. doi: 10.1128/jb.173.6.2045-2052.1991.
Zotero 插件