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本文引用的文献

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Recognition of nitrogen-responsive upstream activation sequences of Saccharomyces cerevisiae by the product of the GLN3 gene.GLN3基因产物对酿酒酵母氮响应上游激活序列的识别。
J Bacteriol. 1995 Jul;177(14):4190-3. doi: 10.1128/jb.177.14.4190-4193.1995.
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Biochemical and physiological aspects of glutamine synthetase inactivation in Saccharomyces cerevisiae.
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Yeast mutants pleiotropically impaired in the regulation of the two glutamate dehydrogenases.酵母突变体在两种谷氨酸脱氢酶的调节中表现出多效性损伤。
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The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.酿酒酵母的URE2基因产物在细胞对氮源的反应中起重要作用，并且与谷胱甘肽S-转移酶具有同源性。
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5
Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain.酿酒酵母的正向氮调节基因GLN3的序列与表达，该基因编码一种具有推定锌指DNA结合结构域的蛋白质。
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酿酒酵母中GATA因子Gln3p与氮调节因子Ure2p的相互作用。

Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae.

作者信息

Blinder D, Coschigano P W, Magasanik B

机构信息

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

出版信息

J Bacteriol. 1996 Aug;178(15):4734-6. doi: 10.1128/jb.178.15.4734-4736.1996.

DOI:10.1128/jb.178.15.4734-4736.1996
PMID:8755910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178249/
Abstract

We used cells carrying plasmids causing the overproduction of Gln3p, Ure2p, or both of these proteins to elucidate the ability of Ure2p to prevent the activation of gene expression by Gln3p in cells growing in a glutamine-containing medium. Our results indicate that Ure2p probably does not interfere with the binding of the GATA factor Gln3p to GATAAG sites but acts directly on Gln3p to block its ability to activate transcription.

摘要

我们使用携带能导致Gln3p、Ure2p或这两种蛋白质过量产生的质粒的细胞，来阐明在含谷氨酰胺培养基中生长的细胞里，Ure2p阻止Gln3p激活基因表达的能力。我们的结果表明，Ure2p可能不会干扰GATA因子Gln3p与GATAAG位点的结合，而是直接作用于Gln3p以阻断其激活转录的能力。