Ertaş M, Uludağ B, Ertekin C
Department of Clinical Neurophysiology and Neurology, Medical School Hospital, Ege University, Izmir, Turkey.
Muscle Nerve. 1996 Aug;19(8):1003-8. doi: 10.1002/(SICI)1097-4598(199608)19:8<1003::AID-MUS8>3.0.CO;2-4.
Motor conduction velocity is expected to be normal or nearly normal in amyotrophic lateral sclerosis (ALS). Some studies have suggested that pathology may be present in the proximal axons. Indeed, some investigators have shown a decrease in the proximal conduction velocity in ALS by using motor conduction velocity measurements and H-reflex and F-response recordings, but they could not delineate the precise region of the conduction pathology. In this study, unlike the ones carried out previously, the most proximal segment has been studied in 11 patients with ALS, 13 normal controls, and 5 patients with sequel of poliomyelitis (SPM) by recording sensory and motor spinal root potentials. While no conduction pathology, H-reflex, or F-response abnormalities were found in ALS patients compared to normal subjects, it was shown that conduction velocity decreased in the proximal segment of the lower motor neuron of the ventral root. Despite motor neuron pathology in SPM, there was no proximal motor conduction slowing compared with that in normal subjects.
在肌萎缩侧索硬化症（ALS）中，运动传导速度预计正常或接近正常。一些研究表明，近端轴突可能存在病变。实际上，一些研究者通过运动传导速度测量以及H反射和F反应记录显示，ALS患者的近端传导速度降低，但他们无法确定传导病变的确切区域。在本研究中，与之前的研究不同，通过记录感觉和运动脊髓神经根电位，对11例ALS患者、13名正常对照者和5例小儿麻痹后遗症（SPM）患者的最近端节段进行了研究。与正常受试者相比，ALS患者未发现传导病变、H反射或F反应异常，但结果显示腹侧神经根下运动神经元的近端节段传导速度降低。尽管SPM存在运动神经元病变，但与正常受试者相比，其近端运动传导并未减慢。
