McGuire W, Hill A V, Greenwood B M, Kwiatkowski D
Department of Paediatrics, John Radcliffe Hospital, Oxford, UK.
Trans R Soc Trop Med Hyg. 1996 May-Jun;90(3):274-6. doi: 10.1016/s0035-9203(96)90244-8.
Intercellular adhesion molecule 1 (ICAM-1) mediates the binding of Plasmodium falciparum to vascular endothelium. In a case-control study of falciparum malaria in Gambian children, we have looked for evidence that a generalized increase in expression of ICAM-1 is associated with cerebral malaria. Plasma levels of circulating ICAM-1 (cICAM-1) were significantly higher in 246 children with acute malaria than in 156 children with non-malarial illnesses. cICAM-1 levels correlated with levels of tumour necrosis factor (TNF), interleukin 1 alpha (IL-1 alpha) and interferon gamma, supporting the view that these cytokines are responsible for a general upregulation of ICAM-1 expression in malaria. However, while it has been previously shown that TNF and IL-1 alpha levels were related to disease severity, this was not the case for cICAM-1. It may be that differences in the distribution of ICAM-1, rather than its total level of expression, are critical in determining the clinical outcome in malaria.
细胞间黏附分子1（ICAM-1）介导恶性疟原虫与血管内皮的结合。在一项针对冈比亚儿童恶性疟的病例对照研究中，我们探寻了ICAM-1表达普遍增加与脑型疟疾相关的证据。246名急性疟疾患儿的循环ICAM-1（cICAM-1）血浆水平显著高于156名非疟疾患儿。cICAM-1水平与肿瘤坏死因子（TNF）、白细胞介素1α（IL-1α）和干扰素γ水平相关，支持了这些细胞因子导致疟疾中ICAM-1表达普遍上调的观点。然而，虽然此前已表明TNF和IL-1α水平与疾病严重程度相关，但cICAM-1并非如此。可能是ICAM-1分布的差异而非其总表达水平在决定疟疾临床结局方面至关重要。
