Meyer G J, Niedermayer W
Med Klin. 1977 Jun 3;72(22):988-92.
The plasma content of folic acid was evaluated in 27 patients with advanced renal disease. There were no significant morphologic changes within the erythrocyts of the peripheral blood and bone marrow. The hematologic response of the reticulocyts, hemoglobin and hematokrit were studied after oral treatment with folic acid. There was a significant reticulocytosis at the 5th to the 8th day after initiating the oral treatment. This reaction underlines a definite, mainly nutritional (latent) folic acid deficiency being one cause for the renal anemia in these patients. A subsequent rise of the hemoglobin or hematocrit did not occur. Further possible causes for these clinical data are being discussed.
对27例晚期肾病患者的血浆叶酸含量进行了评估。外周血和骨髓红细胞内无明显形态学改变。口服叶酸治疗后，研究了网织红细胞、血红蛋白和血细胞比容的血液学反应。口服治疗开始后第5至8天出现明显的网织红细胞增多。这一反应表明，明确的、主要为营养性（潜在性）叶酸缺乏是这些患者肾性贫血的原因之一。随后血红蛋白或血细胞比容并未升高。对这些临床数据的其他可能原因进行了讨论。
