Rønn A M, Msangeni H A, Mhina J, Wernsdorfer W H, Bygbjerg I C
Centre of Medical Parasitology, State University Hospital, Copenhagen, Denmark.
Trans R Soc Trop Med Hyg. 1996 Mar-Apr;90(2):179-81. doi: 10.1016/s0035-9203(96)90129-7.
In many areas of tropical Africa affected by chloroquine-resistant Plasmodium falciparum, a combination of sulfadoxine and pyrimethamine (S-P) is used for alternative medication, especially in young children. In Magoda village in Muheza District, north-eastern Tanzania, 38 children 1-10 years of age were enrolled in a therapeutic study of S-P in July 1994. All had monoinfections of P. falciparum and an asexual parasite count of 1000-80,000/microL of blood. S-P was given as a single dose corresponding to 0.8-1.4 mg pyrimethamine/kg body weight. Of the 38 children followed up to day 7, 10 showed an S/RI response, 26 an RII response, and 2 an RIII response. Older children had lower pre-treatment parasitaemia and a better therapeutic response than younger children. Among the various contributory factors responsible for the poor therapeutic result, drug pressure from a prophylactic intervention with weekly dapsone-pyrimethamine between May 1993 and May 1994 seems to have been the most important.
在非洲热带地区许多受抗氯喹恶性疟原虫影响的区域，磺胺多辛与乙胺嘧啶组合（S-P）被用作替代药物，尤其是用于幼儿。1994年7月，在坦桑尼亚东北部穆赫扎区的马戈达村，38名1至10岁的儿童参加了一项S-P治疗研究。所有儿童均为恶性疟原虫单一感染，无性寄生虫计数为每微升血液1000至80000个。S-P按对应于0.8至1.4毫克乙胺嘧啶/千克体重的单剂量给药。在随访至第7天的38名儿童中，10名表现出S/RI反应，26名表现出RII反应，2名表现出RIII反应。年龄较大的儿童治疗前的寄生虫血症较低，治疗反应优于年龄较小的儿童。在导致治疗效果不佳的各种促成因素中，1993年5月至1994年5月期间每周使用氨苯砜-乙胺嘧啶进行预防性干预产生的药物压力似乎是最重要的因素。
