Torreilles J, Guérin M C, Roch P
CNRS UMR 9947 DRIM, Montpellier, France.
C R Acad Sci III. 1996 Mar;319(3):209-18.
The main results published on the production of reactive oxygen intermediates by hemocytes and digestive glands of marine bivalves such as mussels, oysters or clams have been reviewed and discussed. Mussel and oyster hemocytes respond to appropriate stimuli with a burst of respiratory activity and the generation of reactive oxygen intermediates in a manner resembling the respiratory burst of mammalian phagocytes. However, interspecies differences in hemocytes-mediated antimicrobial defense mechanisms occur since clam hemocytes do not show any increase of reactive oxygen intermediate production upon similar stimulations. Hepatopancreatic gland of bivalves, as mammalian and fish liver produce reactive oxygen species during the one-electron reduction of xenobiotics, and mechanistic differences appear between bivalves and mammals. Thus, it appears that, in spite of some interspecies differences, the generation of cytotoxic reactive oxygen species is a general protective mechanism of most, if not all, animal species.
已对有关贻贝、牡蛎或蛤等海洋双壳贝类血细胞和消化腺产生活性氧中间体的主要研究结果进行了综述和讨论。贻贝和牡蛎血细胞会对适当刺激做出反应，出现呼吸活动爆发，并以类似于哺乳动物吞噬细胞呼吸爆发的方式产生活性氧中间体。然而，血细胞介导的抗菌防御机制存在种间差异，因为蛤血细胞在受到类似刺激时，活性氧中间体的产生并未增加。双壳贝类的肝胰腺，如同哺乳动物和鱼类的肝脏一样，在对外源化合物进行单电子还原过程中产生活性氧，并且双壳贝类和哺乳动物之间存在机制差异。因此，尽管存在一些种间差异，但细胞毒性活性氧的产生似乎是大多数（如果不是全部）动物物种的一种普遍保护机制。
