CGP 36742是一种口服活性GABAB受体拮抗剂，在大鼠的社会识别测试中可促进记忆。
CGP 36,742, an orally active GABAB receptor antagonist, facilitates memory in a social recognition test in rats.
作者信息
Mondadori C, Moebius H J, Zingg M
机构信息
Pharmaceutical Research Department, CIBA-GEIGY Ltd., Basel, Switzerland.
出版信息
Behav Brain Res. 1996 May;77(1-2):227-9. doi: 10.1016/0166-4328(95)00226-x.
CGP 36,742, an orally active GABAB receptor antagonist, improves the retention performance of rats in a social recognition test. This effect is detectable over a very wide range of doses (0.03 to 300 mg/kg, p.o.). Considering its binding (32 mumol affinity for the GABAB site) the surprisingly potent activity of CGP 36,742 makes it appear quite possible that the effect is mediated by an as yet unknown receptor subtype.
CGP 36742是一种口服活性GABAB受体拮抗剂，可改善大鼠在社会识别测试中的记忆保持能力。这种效应在非常宽的剂量范围内（0.03至300毫克/千克，口服）都可检测到。考虑到其结合情况（对GABAB位点的亲和力为32微摩尔），CGP 36742惊人的强效活性使得该效应很有可能是由一种尚未知晓的受体亚型介导的。
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