Kharazia V N, Phend K D, Rustioni A, Weinberg R J
Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599, USA.
Neurosci Lett. 1996 May 24;210(1):37-40. doi: 10.1016/0304-3940(96)12658-6.
Electrophysiology and light microscopy suggest that a single excitatory synapse may use both amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors. Using immunogold electron microscopy, we here provide direct evidence for colocalization at individual synapses in sensorimotor cortex of adult rats. Colocalization was most commonly observed on dendritic spines; subunits of the two classes of receptors seemed to be independently distributed within the synaptic active zone.
电生理学和光学显微镜检查表明，单个兴奋性突触可能同时使用α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）和N-甲基-D-天冬氨酸（NMDA）受体。我们在此利用免疫金电子显微镜，为成年大鼠感觉运动皮层中单个突触处的共定位提供了直接证据。共定位最常见于树突棘；两类受体的亚基似乎在突触活性区内独立分布。
