Kendrey G
Morphol Igazsagugyi Orv Sz. 1977 Apr;17(2):113-7.
Author in the needle-biopsy specimen of the liver of a HBsAg positive patient previously treated with immunosupressive preparates (Corticosteroid + Imuran) in the nuclei of hepatocytes by the aid of electron microscope revealed ring-shaped particula of 20-25 nm in diameter (core), in the cytoplasma of ground-glass hepatocytes in the canals of the rough-surfaced endoplasmic reticulum filamentous formations in average of 23nm in diameter (surface antigen). In addition in a few number cytoplasmic core particula have also been revealed. Dane-particula were not seen. Further in the cytoplasma round or ring-shaped virus-like bodies of unknown origin of 80 nm in diameter were found. These particula could be easily distinguished from the Dane particula and from the B virus components (a second virus infection?). Author believe, that the immunsupressive therapy could play some role in the occurrence of the B virus components, since before the therapy with Imuran they could not be detected in the liver.
作者借助电子显微镜，在一名先前接受免疫抑制制剂（皮质类固醇+硫唑嘌呤）治疗的HBsAg阳性患者的肝脏针吸活检标本中，于肝细胞细胞核内发现了直径为20 - 25纳米的环形颗粒（核心），在粗面内质网管道内毛玻璃样肝细胞的细胞质中发现了平均直径为23纳米的丝状结构（表面抗原）。此外，还发现了少量细胞质核心颗粒。未见到 Dane 颗粒。进一步在细胞质中发现了直径为80纳米、来源不明的圆形或环形病毒样体。这些颗粒很容易与 Dane 颗粒和B病毒成分区分开来（是否为第二种病毒感染？）。作者认为，免疫抑制疗法可能在B病毒成分的出现中起了一定作用，因为在使用硫唑嘌呤治疗之前，在肝脏中未检测到它们。
