Kendrey G
Zentralbl Allg Pathol. 1977;121(4-5):450-5.
In the second liver biopsy material of a seropositive patient receiving immunosuppressive therapy (Corticosteroid + Imuran) for chronic active hepatitis (CAH), intranuclear, ring-shaped, 20--25 nm in diameter non-coated particles (core) of liver cells and intracisternal filaments, 23 nm in diameter (coat) of the soft ER in the "ground-glass" hepatocytes were demonstrated by electron microscopy. Core-particles in the cytoplasm were seen occasionally. Dane-particles could not be visualized. Cytoplasmic spherical and ring-shaped virus-like structures (circ. 80 nm in diameter) different from B-virus components and Dane-particle were also found (second virus-infection?). The role of immuno-suppression in the appaerance of viral structures is considered because such particles could not be detected in the first biopsy before therapy when CAH and antigenaemia were already present.
在一名血清反应阳性患者接受免疫抑制治疗（皮质类固醇+硫唑嘌呤）以治疗慢性活动性肝炎（CAH）的第二次肝活检材料中，通过电子显微镜在“毛玻璃样”肝细胞中发现了肝细胞的核内、环形、直径20 - 25纳米的无包膜颗粒（核心）以及直径23纳米的内质网池内细丝（包膜）。偶尔可见细胞质中的核心颗粒。未观察到丹氏颗粒。还发现了与B病毒成分和丹氏颗粒不同的细胞质球形和环形病毒样结构（直径约80纳米）（第二次病毒感染？）。考虑到在治疗前的第一次活检中，当CAH和抗原血症已经存在时未检测到此类颗粒，因此探讨了免疫抑制在病毒结构出现中的作用。
