Baert J H, Veys R J, Ampe K, De Boever J A
Interdisciplinary Research Center, Katholieke Universiteit Leuven, Belgium.
Int J Exp Pathol. 1996 Apr;77(2):73-8. doi: 10.1046/j.1365-2613.1996.00965.x.
It has recently been shown that triclosan protects the human skin from the inflammation that may be caused by exposure to sodium lauryl sulphate (SLS). The aim of the present study was to examine whether triclosan can protect the hamster cheek pouch mucosa from the irritation caused by exposure to SLS. After four daily applications of a paste containing SLS, the epithelium of the hamster cheek pouch showed consistently prominent structural changes, especially basal hyperplasia, acanthosis, hypergranulosis, and hyperkeratosis. Identical morphological changes were also observed after applications of a paste containing SLS together with triclosan. In contrast, after applications of a paste containing triclosan alone, the cheek pouch mucosa revealed a histological structure essentially similar to the non-treated control mucosa. From these results, we may conclude that SLS, but not triclosan, irritates the hamster cheek pouch epithelium. Moreover, triclosan does not protect the cheek pouch mucosa against structural changes induced by SLS. It must be taken into account that triclosan does not always offer protection against the side-effects of SLS.
最近有研究表明，三氯生可保护人体皮肤免受因接触月桂醇硫酸酯钠（SLS）而可能引发的炎症。本研究的目的是检验三氯生是否能保护仓鼠颊囊黏膜免受接触SLS所引起的刺激。在每日涂抹含SLS的糊剂四次后，仓鼠颊囊的上皮组织持续出现明显的结构变化，尤其是基底细胞增生、棘层增厚、颗粒层增厚和角化过度。在涂抹含SLS和三氯生的糊剂后也观察到了相同的形态学变化。相比之下，在仅涂抹含三氯生的糊剂后，颊囊黏膜的组织结构与未处理的对照黏膜基本相似。从这些结果可以得出结论，刺激仓鼠颊囊上皮组织的是SLS，而非三氯生。此外，三氯生并不能保护颊囊黏膜免受SLS诱导的结构变化影响。必须考虑到，三氯生并非总能预防SLS的副作用。
