人乳头瘤病毒相关子宫颈病变中的腱生蛋白
Tenascin in human papillomavirus associated lesions of the uterine cervix.
作者信息
Pöllänen R, Soini Y, Vuopala S, Läärä E, Lehto V P
机构信息
Department of Pathology, University of Oulu, Finland.
出版信息
J Clin Pathol. 1996 Jun;49(6):521-3. doi: 10.1136/jcp.49.6.521.
The immunohistochemical expression of tenascin was studied in 80 morphologically diagnosed condylomas and cervical intraepithelial neoplasia (CIN) lesions. The results were compared with the human papillomavirus (HPV) DNA subtype, which was determined by HPV dot blot and in situ hybridisation. Tenascin mRNA synthesis was also determined in 10 selected cases by in situ hybridisation. No statistically significant association was found between tenascin expression and the degree of dysplasia or the HPV subtype. There was, however, a strong correlation between the extent of tenascin immunoreactivity and the degree of inflammation. Synthesis of tenascin mRNA was detected in basal keratinocytes and in fibroblasts by in situ hybridisation. The lack of association between the grade of CIN and tenascin expression precludes its use as a marker of premalignancy in CIN.
研究了80例经形态学诊断的尖锐湿疣和宫颈上皮内瘤变（CIN）病变中肌腱蛋白的免疫组化表达情况。将结果与人乳头瘤病毒（HPV）DNA亚型进行比较，后者通过HPV斑点印迹法和原位杂交法测定。还通过原位杂交法在10例选定病例中测定了肌腱蛋白mRNA的合成情况。未发现肌腱蛋白表达与发育异常程度或HPV亚型之间存在统计学上的显著关联。然而，肌腱蛋白免疫反应性的程度与炎症程度之间存在很强的相关性。通过原位杂交法在基底角质形成细胞和成纤维细胞中检测到了肌腱蛋白mRNA的合成。CIN分级与肌腱蛋白表达之间缺乏关联，这使得它无法用作CIN癌前病变的标志物。
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