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1
Evidence for a phosphorylation site in cytomegalovirus glycoprotein gB.巨细胞病毒糖蛋白gB中磷酸化位点的证据。
J Virol. 1996 Aug;70(8):5716-9. doi: 10.1128/JVI.70.8.5716-5719.1996.
2
Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication.人巨细胞病毒糖蛋白B（gB）在酸性簇酪蛋白激酶2位点（Ser900）的磷酸化是gB定位于反式高尔基体网络和有效病毒复制所必需的。
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3
Nuclear translocation of mutagenized forms of human cytomegalovirus glycoprotein B (gpUL55).
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Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900.人巨细胞病毒糖蛋白B（gB）的稳态质膜表达由丝氨酸900的磷酸化状态决定。
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5
Expression, purification, and characterization of a soluble form of human cytomegalovirus glycoprotein B.人巨细胞病毒糖蛋白B可溶性形式的表达、纯化及特性分析
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8
Human cytomegalovirus glycoprotein B contains autonomous determinants for vectorial targeting to apical membranes of polarized epithelial cells.人巨细胞病毒糖蛋白B含有自主决定簇，可将其定向运输至极化上皮细胞的顶端膜。
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Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation.人巨细胞病毒糖蛋白B的突变形式在诱导合胞体形成方面受损。
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10
Identification of the phosphorylation sequence in the cytoplasmic tail of the varicella-zoster virus Fc receptor glycoprotein gpI.水痘带状疱疹病毒Fc受体糖蛋白gpI胞质尾中磷酸化序列的鉴定
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Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblasts.人巨细胞病毒的一种结构成分gpUL132的缺失导致病毒在成纤维细胞中的复制受损。
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The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.自调节结构域的磷酸化状态控制着PACS-1介导的蛋白质运输。
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Phosphorylation of simian cytomegalovirus assembly protein precursor (pAPNG.5) and proteinase precursor (pAPNG1): multiple attachment sites identified, including two adjacent serines in a casein kinase II consensus sequence.猿猴巨细胞病毒装配蛋白前体（pAPNG.5）和蛋白酶前体（pAPNG1）的磷酸化：已鉴定出多个附着位点，包括酪蛋白激酶II共有序列中的两个相邻丝氨酸。
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7
Intracellular formation and processing of the heterotrimeric gH-gL-gO (gCIII) glycoprotein envelope complex of human cytomegalovirus.人巨细胞病毒异源三聚体gH-gL-gO（gCIII）糖蛋白包膜复合物的细胞内形成与加工
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8
Regulation of endosome sorting by a specific PP2A isoform.一种特定的蛋白磷酸酶2A亚型对内涵体分选的调控。
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9
Human cytomegalovirus glycoprotein B contains autonomous determinants for vectorial targeting to apical membranes of polarized epithelial cells.人巨细胞病毒糖蛋白B含有自主决定簇，可将其定向运输至极化上皮细胞的顶端膜。
J Virol. 1998 Sep;72(9):7374-86. doi: 10.1128/JVI.72.9.7374-7386.1998.
10
Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900.人巨细胞病毒糖蛋白B（gB）的稳态质膜表达由丝氨酸900的磷酸化状态决定。
J Virol. 1998 Aug;72(8):6657-64. doi: 10.1128/JVI.72.8.6657-6664.1998.

本文引用的文献

1
Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.蛋白激酶。4. 蛋白激酶CK2：一种具有多种底物且调控方式令人费解的酶。
FASEB J. 1995 Mar;9(5):313-23. doi: 10.1096/fasebj.9.5.7896000.
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Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation.人巨细胞病毒糖蛋白B的突变形式在诱导合胞体形成方面受损。
Virology. 1995 Jun 1;209(2):580-91. doi: 10.1006/viro.1995.1290.
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Glycoprotein B of human cytomegalovirus promotes virion penetration into cells, transmission of infection from cell to cell, and fusion of infected cells.人类巨细胞病毒的糖蛋白B可促进病毒粒子侵入细胞、感染在细胞间的传播以及受感染细胞的融合。
Virology. 1993 Nov;197(1):143-58. doi: 10.1006/viro.1993.1575.
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Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides.从合成肽研究中推导出来的酪蛋白激酶II的底物特异性决定因素。
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Electrospray ionization for mass spectrometry of large biomolecules.用于大型生物分子质谱分析的电喷雾电离
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Human cytomegalovirus strain Towne glycoprotein B is processed by proteolytic cleavage.人巨细胞病毒汤氏株糖蛋白B通过蛋白水解切割进行加工。
Virology. 1988 Nov;167(1):207-25. doi: 10.1016/0042-6822(88)90071-2.

巨细胞病毒糖蛋白gB中磷酸化位点的证据。

Evidence for a phosphorylation site in cytomegalovirus glycoprotein gB.

作者信息

Norais N, Hall J A, Gross L, Tang D, Kaur S, Chamberlain S H, Burke R L, Marcus F

机构信息

Chiron Corporation, Emeryville, California 94608, USA.

出版信息

J Virol. 1996 Aug;70(8):5716-9. doi: 10.1128/JVI.70.8.5716-5719.1996.

DOI:10.1128/JVI.70.8.5716-5719.1996
PMID:8764095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190541/
Abstract

As part of our vaccine program, we have purified a recombinant form of human cytomegalovirus glycoprotein B that is able to induce high titers of virus-neutralizing antibodies. The isolated protein was found to be phosphorylated at a serine residue in position -7 from the C terminus of the protein. The corresponding synthetic peptide, HLKDSDEEENV, was an efficient in vitro substrate of casein kinase II.

摘要

作为我们疫苗计划的一部分，我们纯化了一种重组形式的人巨细胞病毒糖蛋白B，它能够诱导产生高滴度的病毒中和抗体。发现分离出的蛋白质在该蛋白质C末端第7位的丝氨酸残基处被磷酸化。相应的合成肽HLKDSDEEENV是酪蛋白激酶II的有效体外底物。