巨细胞病毒糖蛋白gB中磷酸化位点的证据。
Evidence for a phosphorylation site in cytomegalovirus glycoprotein gB.
作者信息
Norais N, Hall J A, Gross L, Tang D, Kaur S, Chamberlain S H, Burke R L, Marcus F
机构信息
Chiron Corporation, Emeryville, California 94608, USA.
出版信息
J Virol. 1996 Aug;70(8):5716-9. doi: 10.1128/JVI.70.8.5716-5719.1996.
Abstract
As part of our vaccine program, we have purified a recombinant form of human cytomegalovirus glycoprotein B that is able to induce high titers of virus-neutralizing antibodies. The isolated protein was found to be phosphorylated at a serine residue in position -7 from the C terminus of the protein. The corresponding synthetic peptide, HLKDSDEEENV, was an efficient in vitro substrate of casein kinase II.
摘要
作为我们疫苗计划的一部分，我们纯化了一种重组形式的人巨细胞病毒糖蛋白B，它能够诱导产生高滴度的病毒中和抗体。发现分离出的蛋白质在该蛋白质C末端第7位的丝氨酸残基处被磷酸化。相应的合成肽HLKDSDEEENV是酪蛋白激酶II的有效体外底物。
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