Rosenkranz H S, Klopman G
Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
Mutat Res. 1996 Jul 22;354(2):183-93. doi: 10.1016/0027-5107(96)00015-2.
A knowledge-based system (MULTICASE) was applied to the elucidation of the structural basis of the induction of aneuploidy and growth inhibition by a group of chlorinated alkanes and alkenes in Aspergillus nidulans. It was found that while there were commonalities in the structural determinants associated with fungicidal and fungostatic activities, there were none between these and the structures associated with the induction of aneuploidy. Moreover, there did not appear to be a commonality between the structures associated with the induction of aneuploidy and those associated with the induction of mutations in Salmonella.
一个基于知识的系统（MULTICASE）被用于阐明一组氯代烷烃和烯烃在构巢曲霉中诱导非整倍体和生长抑制的结构基础。研究发现，虽然与杀菌和抑菌活性相关的结构决定因素存在共性，但这些与诱导非整倍体的结构之间并无共性。此外，诱导非整倍体的结构与在沙门氏菌中诱导突变的结构之间似乎也没有共性。
