胰腺脂肪酶相关蛋白2而非经典胰腺脂肪酶可水解半乳糖脂。
Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids.
作者信息
Andersson L, Carriére F, Lowe M E, Nilsson A, Verger R
机构信息
Department of Internal Medicine, University of Lund, Sweden.
出版信息
Biochim Biophys Acta. 1996 Aug 16;1302(3):236-40. doi: 10.1016/0005-2760(96)00068-9.
The pancreatic lipase family contains three subfamilies, the 'classical' lipases and the pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2). Galactolipids are present in membranes of leaves and vegetables and consist of digalactosyldiacylglycerol (DGalDG) monogalactosyldiacylglycerol (MGalDG) and sulfoquinovosyldiacylglycerol (SQDG). These lipids were incubated with PLRP2 from guinea-pig (GPLRP2) and rat (RPLRP2). In the presence of bile salts DGalDG was efficiently hydrolyzed by GPLRP2 and, although less efficiently, by RPLRP2 to digalactosylmonoacylglycerol (DGalMG), free fatty acids and water-soluble galactose-containing compounds. Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids.
胰腺脂肪酶家族包含三个亚家族，即“经典”脂肪酶以及胰腺脂肪酶相关蛋白1（PLRP1）和2（PLRP2）。半乳糖脂存在于叶片和蔬菜的膜中，由二半乳糖基二酰基甘油（DGalDG）、单半乳糖基二酰基甘油（MGalDG）和磺基喹喔啉基二酰基甘油（SQDG）组成。这些脂质与来自豚鼠的PLRP2（GPLRP2）和来自大鼠的PLRP2（RPLRP2）一起孵育。在胆汁盐存在的情况下，DGalDG被GPLRP2高效水解，并且虽然效率较低，但也被RPLRP2水解为二半乳糖基单酰基甘油（DGalMG）、游离脂肪酸和水溶性含半乳糖化合物。此外，MGalDG和SQDG也被GPLRP2和RPLRP2水解。这些数据表明PLRP2在膳食半乳糖脂消化中可能发挥作用。
Zotero 插件