Piguet B, Chobaz C, Grounauer P A
Service Universitaire d'Ophtalmologie, Hôpital Jules Gonin, Lausanne.
Klin Monbl Augenheilkd. 1996 May;208(5):358-9. doi: 10.1055/s-2008-1035237.
Referred because of a right corneal perforation with cellular reaction in anterior chamber, a patient was sutured and treated with a single intravitreal injection of 0.2 ml (1 mg) Amikacin and 0.2 ml (1 mg) Vancomycin. Whereas the retina was normal before the injection, a diffuse retinal edema with intra- and preretinal hemorrhages was noted 12 hours postoperatively. Visual acuity was markedly reduced. ERG and visual field was also abnormal.
This case demonstrates that a single intravitreal injection of Amikacin and Vancomycin at usual concentration may induce retinal toxicity with permanent damage.
