Bujía J, Kim C, Bruegel F
Department of Othorhinolaryngology, Ludwig Maximilians University of Munich.
Allergol Immunopathol (Madr). 1996 May-Jun;24(3):112-5.
The etiology and pathogenesis of Bell's palsy are still an enigma. Some studies have reported about the presence of cellular and humoral immune dysfunction in this disease. Recently, determination of soluble interleukin 2 receptor has proven to be a valuable clinical tool to detect dysregulation of T lymphocyte function. The concentrations of soluble interleukin 2 receptor alpha was determined in serum samples from 11 patients with Bell's palsy by an enzyme linked immunosorbent assay (ELISA). Concomitantly 8 age- and sex-matched healthy blood donor as well as six patients with dermatitis herpetiformis served as negative and positive controls, respectively. The concentration of soluble interleukin 2 receptor in serum samples from these patients was similar to that in samples from normal subjects. In contrast to this, patients with dermatitis herpetiformis showed higher values of interleukin 2 receptor. Our results showed that Bell's palsy is not accompanied by a massive activation of T cells.
贝尔面瘫的病因和发病机制仍是一个谜。一些研究报道了该疾病中存在细胞和体液免疫功能障碍。最近，可溶性白细胞介素2受体的测定已被证明是检测T淋巴细胞功能失调的一种有价值的临床工具。通过酶联免疫吸附测定（ELISA）法测定了11例贝尔面瘫患者血清样本中可溶性白细胞介素2受体α的浓度。同时，8名年龄和性别匹配的健康献血者以及6例疱疹样皮炎患者分别作为阴性和阳性对照。这些患者血清样本中可溶性白细胞介素2受体的浓度与正常受试者样本中的浓度相似。与此相反，疱疹样皮炎患者的白细胞介素2受体值较高。我们的结果表明，贝尔面瘫并非伴有T细胞的大量激活。
