Giordani R, Cardenas M L, Moulin-Traffort J, Régli P
Laboratoire de Chimie Bactérienne (LCB), CNRS, Marseille, France.
Mycoses. 1996 Mar-Apr;39(3-4):103-10. doi: 10.1111/j.1439-0507.1996.tb00110.x.
Carica papaya latex sap inhibits the growth of Candida albicans when added to a culture during the exponential growth phase. Approximately 60% was achieved. This fungistatic effect is the result of cell wall degradation due to a lack of polysaccharidic constituents in the outermost layers of the fungal cell wall and release of cell debris into the culture medium. When C. albicans was cultured on medium supplemented with D(+)-glucosamine, an inhibitor of N-acetyl-beta-D-glucosaminidase, growth was inhibited (34%) in a similar manner. Addition of D(+)-glucosamine during the exponential growth phase also had a fungistatic effect (26%). The modes of action of C. papaya latex and of D(+)-glucosamine in cell wall breakdown are discussed.
番木瓜乳胶汁在白色念珠菌指数生长期添加到培养物中时，可抑制其生长，抑菌率约为60%。这种抑菌作用是由于真菌细胞壁最外层多糖成分缺乏导致细胞壁降解，细胞碎片释放到培养基中所致。当白色念珠菌在添加了N-乙酰-β-D-氨基葡萄糖苷酶抑制剂D(+)-氨基葡萄糖的培养基上培养时，生长受到抑制（34%），方式类似。在指数生长期添加D(+)-氨基葡萄糖也有抑菌作用（26%）。文中讨论了番木瓜乳胶汁和D(+)-氨基葡萄糖在细胞壁分解中的作用方式。
