Mirouze J, Selam J L, Pham T C
Nouv Presse Med. 1977 May 21;6(21):1837-41.
With the external artificial pancreas used by the authors, blood glucose is continuously controlled by insulin delivered through an IV infusion and adjusted to two parameters: instantaneous blood glucose levels and increasing or decreasing patterns of blood glucose. The artificial pancreas can be used to treat acute diabetic disorders an to evaluate insulin needs. Furthermore, exogenous insulin homeostasis can be studied: the delay to reach an insulin effect is 18 mm +/- 2 and it remains within 28 mm +/- 2 after the infusion has been stopped; fractional insulin needs are evaluated. From these data, it appears that the efficiency of exogenous insulin exhibits a circadian rhythm.
使用作者所采用的体外人工胰腺时，血糖通过静脉输注的胰岛素持续控制，并根据两个参数进行调整：即时血糖水平以及血糖的上升或下降模式。该人工胰腺可用于治疗急性糖尿病病症并评估胰岛素需求。此外，还可以研究外源性胰岛素稳态：达到胰岛素作用的延迟时间为18分钟±2分钟，在输注停止后该延迟时间仍保持在28分钟±2分钟以内；同时评估胰岛素的需求量。从这些数据来看，外源性胰岛素的效率呈现出昼夜节律。
