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[抗酸剂制剂中铝离子和镁离子释放情况的评估]

[Evaluation of the liberation of aluminum and magnesium ions from preparations made up of antacid ].

作者信息

Pawlaczyk J, Lutka A, Przybylska A

机构信息

Katedra i Zakład Chemii Nieorganicznej i Analitycznej, Akademia Medyczna, Poznań.

出版信息

Acta Pol Pharm. 1992;49(1-2):11-5.

PMID:8769074
Abstract

Releasing of Al3+, Mg2+ and Ca2+ cations from 24 antacid mixtures, 15 from which were prepared in our Department and 9 of foreign origin, during the neutralization reaction of HC10,1 mol/dm3 was determined. Duration of action at pH 3-5 and acid consuming capacity of HCl 1 mol/dm3 acc. to USP XX was also performed. It was stated that magnesium cations were first than Al3+ released from the antacid mixtures during the neutralization reaction.

摘要

测定了24种抗酸混合物在0.1 mol/dm³ HCl中和反应过程中Al³⁺、Mg²⁺和Ca²⁺阳离子的释放情况,其中15种是在我们部门制备的,9种是国外生产的。还根据美国药典XX测定了在pH 3 - 5时的作用持续时间和1 mol/dm³ HCl的酸消耗能力。结果表明,在中和反应过程中,抗酸混合物释放镁阳离子比释放Al³⁺要早。

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