Doorn P F, Mirra J M, Campbell P A, Amstutz H C
Joint Replacement Institute, Los Angeles, CA, USA.
Clin Orthop Relat Res. 1996 Aug(329 Suppl):S187-205. doi: 10.1097/00003086-199608001-00017.
The periprosthetic tissue reaction to polyethylene wear debris in metal on polyethylene total hip replacements is strongly implicated as the cause of osteolysis. This has led to a renewed interest in metal on metal total hip replacements. However, little is known about the role of wear debris in failures of these prostheses. Capsular and interface tissues from 9 long and short term metal on metal total hip replacement retrievals were studied to assess the tissue reaction around these prostheses. As compared with metal on polyethylene cases, the extent of the granulomatous inflammatory reaction and the presence of foreign body type giant cells was much less intense in metal on metal cases, likely because of the lower numbers and overall smaller size of metal wear debris particles. This may lead to a better transport of the particles from the joint tissues and a lower incidence of periprosthetic osteolysis around metal on metal hip replacement.
在金属对聚乙烯全髋关节置换术中，假体周围组织对聚乙烯磨损碎屑的反应被强烈认为是骨溶解的原因。这使得人们对金属对金属全髋关节置换术重新产生了兴趣。然而，对于这些假体失败中磨损碎屑的作用知之甚少。研究了9例长期和短期金属对金属全髋关节置换翻修术中的关节囊和界面组织，以评估这些假体周围的组织反应。与金属对聚乙烯的病例相比，金属对金属病例中的肉芽肿性炎症反应程度和异物型巨细胞的存在要弱得多，这可能是因为金属磨损碎屑颗粒的数量较少且总体尺寸较小。这可能导致颗粒从关节组织的更好运输以及金属对金属髋关节置换周围假体周围骨溶解的发生率较低。
