Doorn P F, Campbell P A, Amstutz H C
Joint Replacement Institute at Orthopaedic Hospital, Los Angeles, CA, USA.
Clin Orthop Relat Res. 1996 Aug(329 Suppl):S206-16. doi: 10.1097/00003086-199608001-00018.
Research has recently been focused on the development of hip replacements with alternative bearing surfaces with cobalt chrome alloy, to avoid the production of polyethylene wear particles in hip replacements and polyethylene wear debris mediated bone lysis. Cobalt chrome on cobalt chrome bearing surfaces are being reevaluated. Characterization of wear particles and studies on the reaction of the body to these particles, have played an important role in the determination of the factors that cause aseptic loosening and will therefore play an important role in the comparison of metal on polyethylene and metal on metal hip prostheses. In this paper, a comparison between the different aspects of metal and polyethylene wear particles is made using data from the literature and the authors' experience. The authors conclude that techniques need to be optimized to isolate and characterize individual metal wear particles from periprosthetic tissues and they advocate the performance of in vitro studies with these in vivo generated wear particles or comparable particles.
最近的研究集中在开发具有钴铬合金替代轴承表面的髋关节置换物，以避免在髋关节置换物中产生聚乙烯磨损颗粒以及聚乙烯磨损碎片介导的骨溶解。钴铬合金对钴铬合金轴承表面正在重新评估。磨损颗粒的表征以及对身体对这些颗粒反应的研究，在确定导致无菌性松动的因素方面发挥了重要作用，因此在比较聚乙烯对金属和金属对金属髋关节假体方面也将发挥重要作用。本文利用文献数据和作者的经验，对金属和聚乙烯磨损颗粒的不同方面进行了比较。作者得出结论，需要优化技术以从假体周围组织中分离和表征单个金属磨损颗粒，他们主张对这些体内产生的磨损颗粒或类似颗粒进行体外研究。
