Hol C, Schalén C, Verduin C M, Van Dijke E E, Verhoef J, Fleer A, Van Dijk H
Eijkman-Winkler Institute, University Hospital, Utrecht, Netherlands.
J Infect Dis. 1996 Sep;174(3):636-8. doi: 10.1093/infdis/174.3.636.
The complement phenotypes of Moraxella catarrhalis isolates obtained from adult patients with acute laryngitis were investigated using a microliter serum bactericidal assay and compared with those of other donor groups. Laryngitis isolates had a higher proportion (57%) of complement-resistant strains than did carrier strains from healthy 8- to 13-year-old schoolchildren (16%). The difference between these groups was statistically significant (chi2 [3 x 2 table] = 21.55; P < .001). The relatively frequent occurrence of the complement-resistant (virulence-associated) phenotype in adults with acute laryngitis supports the theory of an active role of M. catarrhalis in the pathogenesis of acute laryngitis.
采用微量血清杀菌试验研究了从成年急性喉炎患者中分离出的卡他莫拉菌菌株的补体表型，并与其他供体组进行了比较。与来自8至13岁健康学童的携带菌株（16%）相比，喉炎分离株中补体抗性菌株的比例更高（57%）。这些组之间的差异具有统计学意义（卡方检验[3×2列联表]=21.55；P<.001）。在成年急性喉炎患者中补体抗性（与毒力相关）表型相对频繁出现，支持了卡他莫拉菌在急性喉炎发病机制中起积极作用的理论。
