补体抗性是卡他布兰汉菌（摩拉菌）的一种毒力因子。

Complement resistance is a virulence factor of Branhamella (Moraxella) catarrhalis.

作者信息

Hol C, Verduin C M, Van Dijke E E, Verhoef J, Fleer A, van Dijk H

机构信息

Eijkman-Winkler Institute for Medical and Clinical Microbiology, University Hospital, Utrecht, The Netherlands.

出版信息

FEMS Immunol Med Microbiol. 1995 Jun;11(3):207-11. doi: 10.1111/j.1574-695X.1995.tb00118.x.

DOI:10.1111/j.1574-695X.1995.tb00118.x

PMID:7581272

Abstract

The purpose of this study was to investigate complement resistance in Branhamella (Moraxella) catarrhalis isolated from healthy schoolchildren or sputum-producing adult patients. Two techniques were used: a serum bactericidal assay as the gold standard and an easier 'culture and spot' test. Children (age 4-13; n = 303) and patients (n = 1047) showed high colonization/infection rates with B. catarrhalis (31% and 19%, respectively). Complement resistance or intermediate sensitivity occurred frequently in patient isolates (62% and 27%, respectively) and less often in children (33% and 8.5%, respectively; P << 0.0001). In young children (age 4-5 years), the proportion of complement-resistant strains was around 50%. Complement resistance in B. catarrhalis is associated with illness and may hence be considered a virulence factor.

摘要

本研究旨在调查从健康学童或有咳痰症状的成年患者中分离出的卡他布兰汉菌（莫拉菌属）的补体抗性。采用了两种技术：作为金标准的血清杀菌试验和更简便的“培养与斑点”试验。儿童（4至13岁；n = 303）和患者（n = 1047）的卡他布兰汉菌定植/感染率较高（分别为31%和19%）。患者分离株中补体抗性或中度敏感性较为常见（分别为62%和27%），而儿童中则较少见（分别为33%和8.5%；P << 0.0001）。在幼儿（4至5岁）中，补体抗性菌株的比例约为50%。卡他布兰汉菌的补体抗性与疾病相关，因此可被视为一种毒力因子。